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Screening for acute myocarditis — is scintigraphy with 99mTc-Anti-Granulocyte BW 250/183 an answer?
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Abstract
MATERIAL AND METHODS: A two dimensional scintigraphy and SPECT mode of heart imaging with the use of 99mTc-Anti-Granulocyte antibody (740 MBq) was performed on 14 subjects (11 males and 3 females) aged 25–60 years with a positive myocardial biopsy confirming an inflammatory process in the myocardium. After i.v. administration of the tracer a 1 minute series of planar scans was performed within the first 60 minutes. Delayed static scans were performed at 1, 2, 4 and 24 hours.
RESULTS: The scintigraphic scans revealed the uptake of the tracer in the heart area in 13 patients, confirming active inflammatory process. Follow-up scintigraphy was performed 3–5 months after the first study, when the control myocardial biopsy was negative. The results of the study showed the concordance between myocardial biopsy and scintigraphy results in patients with an inflammatory process in the heart.
CONCLUSIONS: Scintigraphy with the use of 99mTc-Anti-Granulocyte seems to be a useful diagnostic method in evaluating patients with suspected myocarditis, but further studies are needed to establish its sensitivity and specificity.
Abstract
MATERIAL AND METHODS: A two dimensional scintigraphy and SPECT mode of heart imaging with the use of 99mTc-Anti-Granulocyte antibody (740 MBq) was performed on 14 subjects (11 males and 3 females) aged 25–60 years with a positive myocardial biopsy confirming an inflammatory process in the myocardium. After i.v. administration of the tracer a 1 minute series of planar scans was performed within the first 60 minutes. Delayed static scans were performed at 1, 2, 4 and 24 hours.
RESULTS: The scintigraphic scans revealed the uptake of the tracer in the heart area in 13 patients, confirming active inflammatory process. Follow-up scintigraphy was performed 3–5 months after the first study, when the control myocardial biopsy was negative. The results of the study showed the concordance between myocardial biopsy and scintigraphy results in patients with an inflammatory process in the heart.
CONCLUSIONS: Scintigraphy with the use of 99mTc-Anti-Granulocyte seems to be a useful diagnostic method in evaluating patients with suspected myocarditis, but further studies are needed to establish its sensitivity and specificity.
Keywords
99mTc-Anti-Granulocyte BW 250/183 antibody; myocardial inflammation; myocarditis; scintigraphy; myocardial biopsy
Title
Screening for acute myocarditis — is scintigraphy with 99mTc-Anti-Granulocyte BW 250/183 an answer?
Journal
Issue
Article type
Brief communication
Pages
165-169
Published online
2004-06-02
Page views
987
Article views/downloads
1034
Bibliographic record
Nucl. Med. Rev 2004;7(2):165-169.
Keywords
99mTc-Anti-Granulocyte BW 250/183 antibody
myocardial inflammation
myocarditis
scintigraphy
myocardial biopsy
Authors
Alicja Hubalewska
Dariusz Dudek
Jacek Dubiel
Ewa Płaczkiewicz-Jankowska
Bohdan Huszno
Anna Staszczak
Wiesław Frasik