open access
Small animal imaging using a conventional gamma camera exemplified in studies on the striatal dopaminergic system
open access
Abstract
MATERIAL AND METHODS: Our pinhole SPECT/MRI approach has been employed in animal models of pre- and postsynaptic dopaminergic dysfunction. The physical characteristics of the scanner, the tracer kinetics and modelling as well as image postprocessing have been addressed and associated intrinsic problems and constraints discussed.
CONCLUSIONS: An outlook has been provided on the application of pinhole SPECT and MRI coregistration towards non-invasive investigations of drug-receptor interactions and binding characteristics of newly developed radiopharmaceuticals.
Abstract
MATERIAL AND METHODS: Our pinhole SPECT/MRI approach has been employed in animal models of pre- and postsynaptic dopaminergic dysfunction. The physical characteristics of the scanner, the tracer kinetics and modelling as well as image postprocessing have been addressed and associated intrinsic problems and constraints discussed.
CONCLUSIONS: An outlook has been provided on the application of pinhole SPECT and MRI coregistration towards non-invasive investigations of drug-receptor interactions and binding characteristics of newly developed radiopharmaceuticals.
Keywords
pinhole SPECT; MRI; coregistration; dopamine transporter; dopamine D2/D3 receptor; striatum
Title
Small animal imaging using a conventional gamma camera exemplified in studies on the striatal dopaminergic system
Journal
Issue
Pages
6-11
Published online
2006-01-25
Page views
469
Article views/downloads
1203
Bibliographic record
Nucl. Med. Rev 2006;9(1):6-11.
Keywords
pinhole SPECT
MRI
coregistration
dopamine transporter
dopamine D2/D3 receptor
striatum
Authors
Christoph Scherfler
Clemens Decristoforo