open access

Vol 13, No 1 (2010)
Published online: 2010-12-01
Submitted: 2012-01-23
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Malignant transformation to schwannoma in a patient affected by type 1 neurofibromatosis as demonstrated by F-18-FDG-PET/CT

Francesco Bertagna, Giovanni Bosio, Giorgio Biasiotto, Simona Fisogni, Luisa Bercich, Raffaele Giubbini
Nucl. Med. Rev 2010;13(1):15-17.

open access

Vol 13, No 1 (2010)
Published online: 2010-12-01
Submitted: 2012-01-23

Abstract

Neurofibromatosis type I (NF1) is an autosomal dominant multisystem disorder. Patients with NF1 are at increased risk for developing both benign and malignant tumours. We report the case of a patient with histologically documented NF1, who underwent F18-FDG-PET/CT for staging purposes. The study revealed intense uptake at multiple masses located at the thighs (the largest presented SUV max of 6.8), popliteal regions, legs, left foot, left supraclavicular region, and at the thoracic wall between the 11th and 12th right ribs. The surgical biopsy of the largest popliteal lesion with higher uptake at F18-FDG-PET/CT documented the presence of a malignant schwannoma at histological examination. In conclusion, F18-FDG-PET/CT was probably able to help the discrimination between benign lesions related to known NF1 and the malignant transformed ones, and to assist clinical decision making.

Nuclear Med Rev 2010; 13, 1: 15–17

Abstract

Neurofibromatosis type I (NF1) is an autosomal dominant multisystem disorder. Patients with NF1 are at increased risk for developing both benign and malignant tumours. We report the case of a patient with histologically documented NF1, who underwent F18-FDG-PET/CT for staging purposes. The study revealed intense uptake at multiple masses located at the thighs (the largest presented SUV max of 6.8), popliteal regions, legs, left foot, left supraclavicular region, and at the thoracic wall between the 11th and 12th right ribs. The surgical biopsy of the largest popliteal lesion with higher uptake at F18-FDG-PET/CT documented the presence of a malignant schwannoma at histological examination. In conclusion, F18-FDG-PET/CT was probably able to help the discrimination between benign lesions related to known NF1 and the malignant transformed ones, and to assist clinical decision making.

Nuclear Med Rev 2010; 13, 1: 15–17

Get Citation

Keywords

PET; neurofibromatosis; malignant degeneration

About this article
Title

Malignant transformation to schwannoma in a patient affected by type 1 neurofibromatosis as demonstrated by F-18-FDG-PET/CT

Journal

Nuclear Medicine Review

Issue

Vol 13, No 1 (2010)

Pages

15-17

Published online

2010-12-01

Bibliographic record

Nucl. Med. Rev 2010;13(1):15-17.

Keywords

PET
neurofibromatosis
malignant degeneration

Authors

Francesco Bertagna
Giovanni Bosio
Giorgio Biasiotto
Simona Fisogni
Luisa Bercich
Raffaele Giubbini

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