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The prognostic value of RDW, NLR and PLR in sequential radio-chemotherapy for advanced lung cancer
- IIIrd Radiotherapy and Chemotherapy Clinic and Teaching Hospital, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
- Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
- Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
- IInd Radiotherapy and Chemotherapy Clinic and Teaching Hospital, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
open access
Abstract
Introduction.Inflammation plays an important role in carcinogenesis, therefore morphology-based inflammatory indices could be prognostic factors in lung cancer patients. This study aimed to analyze if red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are associated with patients’ prognosis in non-small cell lung cancer (NSCLC) patients.
Material and methods.The study population included 110 patients treated with definitive sequential radio-chemotherapy for stage IIIA–IIIB NSCLC. The data were retrospectively analyzed using the receiver operating characteristic (ROC) method, Kaplan-Meier estimator, log-rank testing, and Cox proportional hazards regression model.
Results.The ROC analysis has shown that the optimal cut-off values were 14% for RDW, 2.1 for NLR, and 120 for PLR, with area under the curve (AUC) of 0.606, 0.509, and 0.564 respectively. The overall survival was significantly higher in patients with RDW ≤ 14% with a median survival of 31.2 months compared to 20.2 months for patients with RDW > 14%. RDW was an independent prognostic factor in multivariate analysis.
Conclusions.RDW can provide additional information in assessing patients’ prognosis, but it is necessary to consider its modest sensitivity and specificity. NLR and PLR were not found to be independent prognostic factors.
Abstract
Introduction.Inflammation plays an important role in carcinogenesis, therefore morphology-based inflammatory indices could be prognostic factors in lung cancer patients. This study aimed to analyze if red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are associated with patients’ prognosis in non-small cell lung cancer (NSCLC) patients.
Material and methods.The study population included 110 patients treated with definitive sequential radio-chemotherapy for stage IIIA–IIIB NSCLC. The data were retrospectively analyzed using the receiver operating characteristic (ROC) method, Kaplan-Meier estimator, log-rank testing, and Cox proportional hazards regression model.
Results.The ROC analysis has shown that the optimal cut-off values were 14% for RDW, 2.1 for NLR, and 120 for PLR, with area under the curve (AUC) of 0.606, 0.509, and 0.564 respectively. The overall survival was significantly higher in patients with RDW ≤ 14% with a median survival of 31.2 months compared to 20.2 months for patients with RDW > 14%. RDW was an independent prognostic factor in multivariate analysis.
Conclusions.RDW can provide additional information in assessing patients’ prognosis, but it is necessary to consider its modest sensitivity and specificity. NLR and PLR were not found to be independent prognostic factors.
Keywords
lung cancer; red cell distribution width; RDW
Title
The prognostic value of RDW, NLR and PLR in sequential radio-chemotherapy for advanced lung cancer
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
161-166
Published online
2022-02-11
Page views
4967
Article views/downloads
507
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2022;72(3):161-166.
Keywords
lung cancer
red cell distribution width
RDW
Authors
Iwona Jabłońska
Marcin Miszczyk
Marcin Goławski
Iwona Dębosz-Suwińska
Rafał Suwiński
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