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Vol 71, No 5 (2021)
Research paper (original)
Published online: 2021-08-20
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What new dose distribution statistics may be included in the optimization of dose distribution in radiotherapy for post-mastectomy patients

Piotr Mężeński1, Paweł Kukołowicz1
·
Nowotwory. Journal of Oncology 2021;71(5):267-273.
Affiliations
  1. Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

open access

Vol 71, No 5 (2021)
Original article
Published online: 2021-08-20

Abstract

Introduction. The main aim of this study was to evaluate the doses delivered to heart substructures and calculate normal tissue complication probability (NTCP) for the intensity modulation radiotherpy (IMRT) irradiated group of left-sided post-mastectomy patients.

Material and methods. In this retrospective study for 30 randomly chosen breast cancer patients, the mean dose, V2, V4, V10, V20 and D2% in the heart substructures were evaluated.

Results. The mean heart dose was 12.3 Gy, the mean left anterior descending artery (LAD) dose was 28.5 Gy. The average value of long-term cardiac mortality was 0.17%, pericarditis 0.0%, left ventricle perfusion defects 24.5% and LAD toxicity 0.2%. In the literature, for the IMRT technique for left-sided mastectomy patients, the mean heart dose ranged from 8.7–14.0 Gy and the V20 10.5–14%. Additional studies are needed to describe the cardiac toxicity.

Conclusions. It is necessary to contour cardiac substructures for reliable assessment of the dose distribution, although the mean heart dose is simplification for modern radiotherapy techniques.

Abstract

Introduction. The main aim of this study was to evaluate the doses delivered to heart substructures and calculate normal tissue complication probability (NTCP) for the intensity modulation radiotherpy (IMRT) irradiated group of left-sided post-mastectomy patients.

Material and methods. In this retrospective study for 30 randomly chosen breast cancer patients, the mean dose, V2, V4, V10, V20 and D2% in the heart substructures were evaluated.

Results. The mean heart dose was 12.3 Gy, the mean left anterior descending artery (LAD) dose was 28.5 Gy. The average value of long-term cardiac mortality was 0.17%, pericarditis 0.0%, left ventricle perfusion defects 24.5% and LAD toxicity 0.2%. In the literature, for the IMRT technique for left-sided mastectomy patients, the mean heart dose ranged from 8.7–14.0 Gy and the V20 10.5–14%. Additional studies are needed to describe the cardiac toxicity.

Conclusions. It is necessary to contour cardiac substructures for reliable assessment of the dose distribution, although the mean heart dose is simplification for modern radiotherapy techniques.

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Keywords

heart; breast cancer; post-mastectomy; IMRT; NTCP

About this article
Title

What new dose distribution statistics may be included in the optimization of dose distribution in radiotherapy for post-mastectomy patients

Journal

Nowotwory. Journal of Oncology

Issue

Vol 71, No 5 (2021)

Article type

Research paper (original)

Pages

267-273

Published online

2021-08-20

Page views

5822

Article views/downloads

361

DOI

10.5603/NJO.a2021.0047

Bibliographic record

Nowotwory. Journal of Oncology 2021;71(5):267-273.

Keywords

heart
breast cancer
post-mastectomy
IMRT
NTCP

Authors

Piotr Mężeński
Paweł Kukołowicz

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