open access

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Research paper (original)
Published online: 2021-06-09
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Does Epidural Analgesia modify the risk of complications after gastrectomy

Tomasz Olesiński, Marta Urbańska, Anna Borkowska, Paulina Wieszczy, Dariusz Król, Dorota Rucz, Małgorzata Symonides
DOI: 10.5603/NJO.a2021.0030

open access

Ahead of print
Original article
Published online: 2021-06-09

Abstract

Background: The surgical treatment of Gastric Cancer is associated with overall complication rates as high as 50%. The intent of this study was to assess the impact of epidural analgesia (EA) on postoperative complication rates among patients undergoing gastric resections. Methods: Of 617 gastric cancer patients who between 2002 and 2010 had undergone stomach resection 246 (39.8%) were administered EA. Groups with and without EA were compared Results: General complications rate was lower in the EA group in univariable analysis – 38.5% vs 54.2% (OR 0.47; 95% CI:0.34-0.66; p<0.001), intra-abdominal abscess (OR 0,28; 95%CI:0.14-0.59; p=0.001), pneumonia (OR 0,39; 95%CI: 0.24-0.63; p<0.001), temperature >38(C)(OR 0,53; 95%CI:0.37-0.74; p<0.001) and re-operation (OR 0,53; 95%CI:0.28-1.00; p=0.049). These relationships were confirmed in a multivariable analysis for the general number of complications (OR 0,53; 95%CI:0.37-0.75; p<0.001), intraabdominal abscess (OR 0,36; 95%CI:0.16-0.77; p=0.009) temperature >38(C)(OR 0,56; 95%CI:0.39-0.82; p=0.009) pneumonia (OR 0,42; 95%CI: 0.25-0.71; p=0.001). Conclusion: Our findings indicate that postoperative treatment with EA for patients undergoing stomach resection is safe and contributes to a reduction in the number of postoperative complications.

Abstract

Background: The surgical treatment of Gastric Cancer is associated with overall complication rates as high as 50%. The intent of this study was to assess the impact of epidural analgesia (EA) on postoperative complication rates among patients undergoing gastric resections. Methods: Of 617 gastric cancer patients who between 2002 and 2010 had undergone stomach resection 246 (39.8%) were administered EA. Groups with and without EA were compared Results: General complications rate was lower in the EA group in univariable analysis – 38.5% vs 54.2% (OR 0.47; 95% CI:0.34-0.66; p<0.001), intra-abdominal abscess (OR 0,28; 95%CI:0.14-0.59; p=0.001), pneumonia (OR 0,39; 95%CI: 0.24-0.63; p<0.001), temperature >38(C)(OR 0,53; 95%CI:0.37-0.74; p<0.001) and re-operation (OR 0,53; 95%CI:0.28-1.00; p=0.049). These relationships were confirmed in a multivariable analysis for the general number of complications (OR 0,53; 95%CI:0.37-0.75; p<0.001), intraabdominal abscess (OR 0,36; 95%CI:0.16-0.77; p=0.009) temperature >38(C)(OR 0,56; 95%CI:0.39-0.82; p=0.009) pneumonia (OR 0,42; 95%CI: 0.25-0.71; p=0.001). Conclusion: Our findings indicate that postoperative treatment with EA for patients undergoing stomach resection is safe and contributes to a reduction in the number of postoperative complications.

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Keywords

gastric cancer, GEJ cancer, epidural analgesia, postoperative complications, gastrectomy, postoperative pain

About this article
Title

Does Epidural Analgesia modify the risk of complications after gastrectomy

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Research paper (original)

Published online

2021-06-09

DOI

10.5603/NJO.a2021.0030

Keywords

gastric cancer
GEJ cancer
epidural analgesia
postoperative complications
gastrectomy
postoperative pain

Authors

Tomasz Olesiński
Marta Urbańska
Anna Borkowska
Paulina Wieszczy
Dariusz Król
Dorota Rucz
Małgorzata Symonides

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