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Mixed variant of mucinous breast cancer seen in the Oncology Centre in Krakow: clinical characteristics and treatment results in patients treated 1975–2005
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Abstract
Introduction. Mucinous breast carcinoma (MBC) accounts for approximately 2–3% of all breast cancer types. The purpose of this study is to present the clinico-pathological characteristics and treatment results in patients treated for mixed variant of MBC.
Material and methods. We analysed 50 patients with M-MBC treated between 1975 and 2005. The mean age was 64 years, and 86% patients presented with stage I or II breast cancer, involved lymph nodes were observed in 26%, and hormonal receptors positivity was found in 70% cases. All patients received surgical treatment: mastectomy (43 — 86%) or breast-conserving therapy (7 — 14%). The adiuvant treatment consisted of radiotherapy (24 — 48%), chemotherapy (13 — 26%).
Results. The 10-year disease-free survival (DFS) rate was 64%. Univariate and multivariate analyses showed that an independent statistically significant prognostic factor was the microscopic status of axillary lymph nodes (pN). 10-year DFS according to pN was 81.1% for pN0 and 15.4% for pN+. During the follow-up 16 patients (32%) developed distant metastases.
Conclusions. M-MBC is characterised by the following: high ratio of lower stage disease, hormonal receptors positivity and relatively lower incidence of involved axillary lymph nodes.
Abstract
Introduction. Mucinous breast carcinoma (MBC) accounts for approximately 2–3% of all breast cancer types. The purpose of this study is to present the clinico-pathological characteristics and treatment results in patients treated for mixed variant of MBC.
Material and methods. We analysed 50 patients with M-MBC treated between 1975 and 2005. The mean age was 64 years, and 86% patients presented with stage I or II breast cancer, involved lymph nodes were observed in 26%, and hormonal receptors positivity was found in 70% cases. All patients received surgical treatment: mastectomy (43 — 86%) or breast-conserving therapy (7 — 14%). The adiuvant treatment consisted of radiotherapy (24 — 48%), chemotherapy (13 — 26%).
Results. The 10-year disease-free survival (DFS) rate was 64%. Univariate and multivariate analyses showed that an independent statistically significant prognostic factor was the microscopic status of axillary lymph nodes (pN). 10-year DFS according to pN was 81.1% for pN0 and 15.4% for pN+. During the follow-up 16 patients (32%) developed distant metastases.
Conclusions. M-MBC is characterised by the following: high ratio of lower stage disease, hormonal receptors positivity and relatively lower incidence of involved axillary lymph nodes.
About this articleTitle
Mixed variant of mucinous breast cancer seen in the Oncology Centre in Krakow: clinical characteristics and treatment results in patients treated 1975–2005
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
97-102
Published online
2016-06-01
Page views
737
Article views/downloads
4474
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2016;66(2):97-102.
Authors
Piotr Skotnicki
Łukasz Strzępek
Beata Sas-Korczyńska
Marian Reinfuss
Tomasz Walasek
Anna Patla