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Prognostic factors of brain metastases in patients with breast cancer
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Abstract
The development of brain metastases from breast cancer (BMBC) relates to poor prognosis. The median survival rate averages from 2 to 16 months and depends on various prognostic factors and therapeutic possibilities. There are some prognostic factors which were found in trials as a results of multivariate analyses and factors from prognostic scores in patients with brain metastases. According to the literature the important prognostic factors are performance status and status of the disease outside the brain. Performance status usually is evaluated according to the Karnofsky scale. Whereas the disease status is estimated variously as: presence versus no disease, controlled or uncontrolled disease, presence or not of distant metastases outside the brain. Many authors revealed that age, molecular type of breast cancer and number of brain metastases are potential prognostic factors. Published results of analyses showed that the role of some prognostic factors is limited in patients with BMBC.
Abstract
The development of brain metastases from breast cancer (BMBC) relates to poor prognosis. The median survival rate averages from 2 to 16 months and depends on various prognostic factors and therapeutic possibilities. There are some prognostic factors which were found in trials as a results of multivariate analyses and factors from prognostic scores in patients with brain metastases. According to the literature the important prognostic factors are performance status and status of the disease outside the brain. Performance status usually is evaluated according to the Karnofsky scale. Whereas the disease status is estimated variously as: presence versus no disease, controlled or uncontrolled disease, presence or not of distant metastases outside the brain. Many authors revealed that age, molecular type of breast cancer and number of brain metastases are potential prognostic factors. Published results of analyses showed that the role of some prognostic factors is limited in patients with BMBC.
About this articleTitle
Prognostic factors of brain metastases in patients with breast cancer
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
496-503
Published online
2015-01-08
Page views
822
Article views/downloads
3363
DOI
10.5603/NJO.2014.0086
Bibliographic record
Nowotwory. Journal of Oncology 2014;64(6):496-503.
Authors
Tomasz Walasek
Beata Sas-Korczyńska
Paweł Blecharz
Jerzy W. Mituś
Marian Reinfuss