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Importance and usefulness of diagnostic metaloproteinases in breast cancer
open access
Abstract
Breast cancer is the second highest cause of death of Polish women with cancer. Modern methods for cancer diagnostics are insufficient, and therefore also for searching for new tumour markers. One is the matrix metaloproteinases (MMPs). Proper regulation of metaloproteinase activity is important in the formation and development of cancer. Also the different stages of cancer are characterized by changes in the activity of matrix metaloproteinases. Especially MMPs-1, MMP-2, MMP-8, MMP-9 and MMP-11 play a key role as their expression is associated with a reduction of tumour invasiveness. These enzymes are an important factor to determine the severity of the disease, which can significantly facilitate the further course of forecasting and selection of appropriate therapy.
Abstract
Breast cancer is the second highest cause of death of Polish women with cancer. Modern methods for cancer diagnostics are insufficient, and therefore also for searching for new tumour markers. One is the matrix metaloproteinases (MMPs). Proper regulation of metaloproteinase activity is important in the formation and development of cancer. Also the different stages of cancer are characterized by changes in the activity of matrix metaloproteinases. Especially MMPs-1, MMP-2, MMP-8, MMP-9 and MMP-11 play a key role as their expression is associated with a reduction of tumour invasiveness. These enzymes are an important factor to determine the severity of the disease, which can significantly facilitate the further course of forecasting and selection of appropriate therapy.
Title
Importance and usefulness of diagnostic metaloproteinases in breast cancer
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
491-495
Published online
2015-01-08
Page views
994
Article views/downloads
4411
DOI
10.5603/NJO.2014.0085
Bibliographic record
Nowotwory. Journal of Oncology 2014;64(6):491-495.
Authors
Ilona Zaręba
Magdalena Donejko
Edyta Rysiak