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Published online: 2023-11-20
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Advances in management of pheochromocytoma – a short review

Michał Miciak1, Krzysztof Jurkiewicz1, Krzysztof Kaliszewski1
Affiliations
  1. Department of General, Minimally Invasive and Endocrine Surgery Wroclaw Medical University, Wrocław, Poland

open access

Ahead of print
Review articles – Pheochromocytoma
Published online: 2023-11-20

Abstract

Pheochromocytoma is a rare neuroendocrine neoplasm. It is characterized by overproduction of catecholamines, which causes clinical symptoms associated with elevated blood pressure values and can even lead to life-threatening complications. The tumor can be associated with genetic syndromes such as MEN-2 or VHL, and currently available and constantly evolving genetic testing makes it possible to detect the inherited form and plan appropriate therapy. Management of pheochromocytoma is based on initial laboratory diagnosis, confirmation by imaging studies, determination of hormonal activity and resulting therapy. Surgical resection by laparoscopic approach is the most recommended. For unresectable tumor or advanced disease with distant metastases, systemic therapies developing all the time currently allow cure or inhibition of tumor progression. In this paper, we will review advances in management of pheochromocytoma over the past decade and potential directions for future research.

Abstract

Pheochromocytoma is a rare neuroendocrine neoplasm. It is characterized by overproduction of catecholamines, which causes clinical symptoms associated with elevated blood pressure values and can even lead to life-threatening complications. The tumor can be associated with genetic syndromes such as MEN-2 or VHL, and currently available and constantly evolving genetic testing makes it possible to detect the inherited form and plan appropriate therapy. Management of pheochromocytoma is based on initial laboratory diagnosis, confirmation by imaging studies, determination of hormonal activity and resulting therapy. Surgical resection by laparoscopic approach is the most recommended. For unresectable tumor or advanced disease with distant metastases, systemic therapies developing all the time currently allow cure or inhibition of tumor progression. In this paper, we will review advances in management of pheochromocytoma over the past decade and potential directions for future research.

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Keywords

pheochromocytoma; management; imaging studies; systemic therapy; advances

About this article
Title

Advances in management of pheochromocytoma – a short review

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Review paper

Published online

2023-11-20

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18

Article views/downloads

26

Keywords

pheochromocytoma
management
imaging studies
systemic therapy
advances

Authors

Michał Miciak
Krzysztof Jurkiewicz
Krzysztof Kaliszewski

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