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Vol 57, No 3 (2023)
Review Article
Submitted: 2022-11-11
Accepted: 2023-01-17
Published online: 2023-03-17
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Sleep disturbances in progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS)

Piotr Alster1, Natalia Madetko-Alster1, Anna Migda2, Bartosz Migda3, Michał Kutyłowski4, Leszek Królicki5, Andrzej Friedman1
DOI: 10.5603/PJNNS.a2023.0019
·
Pubmed: 36928793
·
Neurol Neurochir Pol 2023;57(3):229-234.
Affiliations
  1. Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03/242 Warsaw, Poland
  2. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
  3. Diagnostic Ultrasound Lab, Department of Pediatric Radiology, Medical University of Warsaw, Warsaw, Poland
  4. Department of Radiology, Mazovian Brodno Hospital, Warsaw, Poland
  5. Department of Nuclear Medicine, Medical University of Warsaw, Warsaw, Poland

open access

Vol 57, No 3 (2023)
Review articles
Submitted: 2022-11-11
Accepted: 2023-01-17
Published online: 2023-03-17

Abstract

Introduction. Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical manifestations of tauopathies. They are commonly associated with rapid motor and cognitive deterioration. Sleep disturbances are less frequently described as a feature of these diseases, though they are reported among 50-75% of PSP patients.

State of the art. Apart from various clinical manifestations, sleep abnormalities in PSP and CBS seem to be a factor enhancing pathogenesis as well its consequences. Multiple researchers have looked into the issue of whether the complexity of sleep disturbances in PSP and CBS could be linked to atrophic changes within structures crucial for daytime regulation, coexisting pathologies, or other less explored mechanisms.

Clinical significance. Among sleep abnormalities in PSP and CBS have been reported excessive daytime sleepiness, night-time insomnia, reduction of total sleep time, more pronounced sleep fragmentation, restless leg syndrome (RLS), agrypnia excitata, periodic limb movements, sleep respiratory disturbances, rapid-eye movement behaviour disorder, and others.

Future directions. The aim of this review was to elaborate upon the significance of sleep abnormalities in tauopathic parkinsonian syndromes, and to determine their usefulness in differential diagnosis with synucleinopathic parkinsonian syndromes. Extended analyses of sleep disturbances may provide a different perspective on atypical parkinsonisms.

Abstract

Introduction. Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical manifestations of tauopathies. They are commonly associated with rapid motor and cognitive deterioration. Sleep disturbances are less frequently described as a feature of these diseases, though they are reported among 50-75% of PSP patients.

State of the art. Apart from various clinical manifestations, sleep abnormalities in PSP and CBS seem to be a factor enhancing pathogenesis as well its consequences. Multiple researchers have looked into the issue of whether the complexity of sleep disturbances in PSP and CBS could be linked to atrophic changes within structures crucial for daytime regulation, coexisting pathologies, or other less explored mechanisms.

Clinical significance. Among sleep abnormalities in PSP and CBS have been reported excessive daytime sleepiness, night-time insomnia, reduction of total sleep time, more pronounced sleep fragmentation, restless leg syndrome (RLS), agrypnia excitata, periodic limb movements, sleep respiratory disturbances, rapid-eye movement behaviour disorder, and others.

Future directions. The aim of this review was to elaborate upon the significance of sleep abnormalities in tauopathic parkinsonian syndromes, and to determine their usefulness in differential diagnosis with synucleinopathic parkinsonian syndromes. Extended analyses of sleep disturbances may provide a different perspective on atypical parkinsonisms.

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Keywords

progressive supranuclear palsy, corticobasal syndrome, CBS, PSP, sleep disturbances

About this article
Title

Sleep disturbances in progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS)

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 57, No 3 (2023)

Article type

Review Article

Pages

229-234

Published online

2023-03-17

Page views

1717

Article views/downloads

1057

DOI

10.5603/PJNNS.a2023.0019

Pubmed

36928793

Bibliographic record

Neurol Neurochir Pol 2023;57(3):229-234.

Keywords

progressive supranuclear palsy
corticobasal syndrome
CBS
PSP
sleep disturbances

Authors

Piotr Alster
Natalia Madetko-Alster
Anna Migda
Bartosz Migda
Michał Kutyłowski
Leszek Królicki
Andrzej Friedman

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