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Vol 56, No 2 (2022)
Invited Review Article
Submitted: 2020-08-09
Accepted: 2021-10-21
Published online: 2021-12-16
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Central nervous system autopsy — a neuropathological procedure based on multidisciplinary pathoclinical cooperation

Aleksandra Sejda1, Teresa Wierzba-Bobrowicz2, Dariusz Adamek3, Jacek Gulczyński4, Sławomir Michalak5, Wiesława Grajkowska6, Ewa Iżycka-Świeszewska4
DOI: 10.5603/PJNNS.a2021.0088
·
Pubmed: 34913473
·
Neurol Neurochir Pol 2022;56(2):118-130.
Affiliations
  1. Pathomorphology Department, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
  2. Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
  3. Department of Pathology, Jagiellonian University Medical College, Krakow, Poland
  4. Department of Pathology and Neuropathology, Medical University of Gdansk, Poland
  5. Department of Neurology, Division of Neurochemistry and Neuropathology, Poznan University of Medical Science, Poznan, Poland
  6. Department of Pathology, Children’s Memorial Health Institute, Warsaw, Poland

open access

Vol 56, No 2 (2022)
Invited review articles
Submitted: 2020-08-09
Accepted: 2021-10-21
Published online: 2021-12-16

Abstract

Introduction: Neuropathological brain and spinal cord post mortem examination is a distinct procedure that still plays an important role in modern medicine. In front of increasing amounts of clinical and genetic data, together with important developments in the field of neuroimaging, the Polish Association of Neuropathologists have updated their recommendations regarding central nervous system (CNS) examination. These guidelines are aimed at neuropathologists, pathologists and clinicians.

Aim of the study: Presentation of the outlined recommendations as their goal is to improve the quality, informativity, and cost effectiveness of CNS post mortem examinations. A comprehensive study of the literature was conducted to provide a clinical background of neuropathological autopsy. There are numerous open questions in neuroscience, and new strategies are required to foster research in CNS diseases. These include the challenge of organizing brain banks tasked with managing and protecting detailed multidisciplinary information about their resources. Complex neuropathological analyses of post mortem series are also important to assess the effectiveness of diagnostics and therapy, identify environmental impact on the development of neurological disorders, and improve public health policy. The recommendations outline the need for collaboration between multiple specialists to establish the proper diagnosis and to broaden knowledge of neurological disorders.

Abstract

Introduction: Neuropathological brain and spinal cord post mortem examination is a distinct procedure that still plays an important role in modern medicine. In front of increasing amounts of clinical and genetic data, together with important developments in the field of neuroimaging, the Polish Association of Neuropathologists have updated their recommendations regarding central nervous system (CNS) examination. These guidelines are aimed at neuropathologists, pathologists and clinicians.

Aim of the study: Presentation of the outlined recommendations as their goal is to improve the quality, informativity, and cost effectiveness of CNS post mortem examinations. A comprehensive study of the literature was conducted to provide a clinical background of neuropathological autopsy. There are numerous open questions in neuroscience, and new strategies are required to foster research in CNS diseases. These include the challenge of organizing brain banks tasked with managing and protecting detailed multidisciplinary information about their resources. Complex neuropathological analyses of post mortem series are also important to assess the effectiveness of diagnostics and therapy, identify environmental impact on the development of neurological disorders, and improve public health policy. The recommendations outline the need for collaboration between multiple specialists to establish the proper diagnosis and to broaden knowledge of neurological disorders.

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Keywords

brain and spinal cord dissection, guidelines, neuropathology, pathoclinical cooperation

About this article
Title

Central nervous system autopsy — a neuropathological procedure based on multidisciplinary pathoclinical cooperation

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 56, No 2 (2022)

Article type

Invited Review Article

Pages

118-130

Published online

2021-12-16

Page views

5312

Article views/downloads

2116

DOI

10.5603/PJNNS.a2021.0088

Pubmed

34913473

Bibliographic record

Neurol Neurochir Pol 2022;56(2):118-130.

Keywords

brain and spinal cord dissection
guidelines
neuropathology
pathoclinical cooperation

Authors

Aleksandra Sejda
Teresa Wierzba-Bobrowicz
Dariusz Adamek
Jacek Gulczyński
Sławomir Michalak
Wiesława Grajkowska
Ewa Iżycka-Świeszewska

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