open access

Vol 56, No 2 (2022)
Letter to the Editors
Submitted: 2021-05-20
Accepted: 2021-09-29
Published online: 2021-10-27
Get Citation

Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Pavel Štourač1, Jana Bednářová2, Zbyšek Pavelek3, Martin Vališ3
·
Pubmed: 34704603
·
Neurol Neurochir Pol 2022;56(2):187-190.
Affiliations
  1. Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
  2. Department of Clinical Microbiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
  3. Department of Neurology, University Hospital Hradec Králové and Faculty of Medicine, Charles University, Hradec Králové, Czech Republic

open access

Vol 56, No 2 (2022)
Letters to the Editors
Submitted: 2021-05-20
Accepted: 2021-09-29
Published online: 2021-10-27

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

anti-Hu, anti-GAD antibodies, primary progressive multiple sclerosis, overlapping syndromes

About this article
Title

Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 56, No 2 (2022)

Article type

Letter to the Editors

Pages

187-190

Published online

2021-10-27

Page views

5125

Article views/downloads

901

DOI

10.5603/PJNNS.a2021.0078

Pubmed

34704603

Bibliographic record

Neurol Neurochir Pol 2022;56(2):187-190.

Keywords

anti-Hu
anti-GAD antibodies
primary progressive multiple sclerosis
overlapping syndromes

Authors

Pavel Štourač
Jana Bednářová
Zbyšek Pavelek
Martin Vališ

References (16)
  1. Titulaer MJ, Höftberger R, Iizuka T, et al. Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis. Ann Neurol. 2014; 75(3): 411–428.
  2. Naik S, Kolikonda MK, Lippmann S. Progressive encephalomyelitis with rigidity: stiff person syndrome variant associated with multiple sclerosis. Prim Care Companion CNS Disord. 2019; 21(1).
  3. Thompson A, Banwell B, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. The Lancet Neurology. 2018; 17(2): 162–173.
  4. Pellizza F, Nobile-Orazio O, Giometto B. Neuronal Nuclear Antibodies ,Type 1(Hu). In: Shoenfeld Y, Meroni PI, Gershwin ME. ed. Autoantibodies. Elsevier 2014.
  5. Graus F, Saiz A, Dalmau J. GAD antibodies in neurological disorders - insights and challenges. Nat Rev Neurol. 2020; 16(7): 353–365.
  6. Hadjivassiliou M, Martindale J, Shanmugarajah P, et al. Causes of progressive cerebellar ataxia: prospective evaluation of 1500 patients. J Neurol Neurosurg Psychiatry. 2017; 88(4): 301–309.
  7. Nanri K, Okuma M, Sato S, et al. Prevalence of autoantibodies and the efficacy of immunotherapy for autoimmune cerebellar ataxia. Intern Med. 2016; 55(5): 449–454.
  8. Herard K, Khanni J, Hibbert KA, et al. Neurological disorders associated with glutamic acid decarboxylase antibodies. Cureus. 2019.
  9. Meinck HM, Faber L, Morgenthaler N, et al. Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. J Neurol Neurosurg Psychiatry. 2001; 71(1): 100–103.
  10. Dalakas MC, Fujii M, Li M, et al. The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology. 2000; 55(10): 1531–1535.
  11. Honnorat J, Saiz A, Giometto B, et al. Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients. Arch Neurol. 2001; 58(2): 225–230.
  12. Cianci V, Labate A, et al. Non-paraneoplastic limbic encephalitis characterized by mesio-temporal seizures and extratemporal lesions: case report . Seizure. 2010; 19(7): 446–449.
  13. Duell F, Evertsson B, Al Nimer F, et al. Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS. Neurol Neuroimmunol Neuroinflamm. 2020; 7(4).
  14. Hottenrott T, Dersch R, Berger B, et al. The MRZ reaction in primary progressive multiple sclerosis. Fluids Barriers CNS. 2017; 14(1): 2.
  15. Senties-Madrid H, Vega-Boada F. Paraneoplastic syndromes associated with anti-Hu antibodies. Isr Med Assoc J. 2001; 3(2): 94–103.
  16. Li J, Lin W. Various clinical features of patients with anti-Hu associated paraneoplastic neurological syndromes: An observational study. Medicine (Baltimore). 2018; 97(18): e0649.

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