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Neuroimaging in Parkinson’s Disease: necessity or exaggeration?
Affiliations- Department of Neurology, Regional Specialist Hospital im. Św. Barbary in Sosnowiec, Poland
- Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland
- Academic Research Center AKAMED, Torun, Poland
- Department of Nuclear Medicine, Medical University of Gdansk, Poland
- Department of Neurology & Stroke, St. Adalbert Hospital, Gdańsk, Poland
- Division of Neurological and Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdansk, Poland
- Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Poland, Poland
- Department of Radiology, City Hospital in Sosnowiec, Poland
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Abstract
Introduction: Neuroimaging plays an increasingly important role in the diagnosis of parkinsonian syndromes. Aim of the study: In this paper, the authors elaborate on the necessity of using magnetic resonance imaging (MRI) in Parkinson’s Disease (PD) and its potential role in differential diagnosis versus other neurodegenerative parkinsonian syndromes such as dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy and corticobasal syndrome. State of the art: The currently known characteristic abnormalities are listed and tabulated, current recommendations are summarised and sample images are provided. As routine MRI scanning in PD remains controversial, the authors’ aim is to show the pros and cons in clinical practice. Additionally, the rationale for functional imaging examination, including [123I]-FP-CIT SPECT (DaTSCAN) and [99mTc]- HMPAO-SPECT, [18F]-FDG-PET, [123I]-mIBG-SPECT is discussed. Clinical vignette: This paper is accompanied by two illustrative clinical cases in which neuroimaging studies played a key role in diagnosis and further management. Conclusions: Neuroimaging can be helpful in differentiating PD from both atypical and symptomatic parkinsonism. Nevertheless, extensive neurological assessment in a majority of PD cases is sufficient to make a diagnosis. A network of specialists in movement disorders should be established in order to enable better, faster and more precise diagnosis of parkinsonism.
Abstract
Introduction: Neuroimaging plays an increasingly important role in the diagnosis of parkinsonian syndromes. Aim of the study: In this paper, the authors elaborate on the necessity of using magnetic resonance imaging (MRI) in Parkinson’s Disease (PD) and its potential role in differential diagnosis versus other neurodegenerative parkinsonian syndromes such as dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy and corticobasal syndrome. State of the art: The currently known characteristic abnormalities are listed and tabulated, current recommendations are summarised and sample images are provided. As routine MRI scanning in PD remains controversial, the authors’ aim is to show the pros and cons in clinical practice. Additionally, the rationale for functional imaging examination, including [123I]-FP-CIT SPECT (DaTSCAN) and [99mTc]- HMPAO-SPECT, [18F]-FDG-PET, [123I]-mIBG-SPECT is discussed. Clinical vignette: This paper is accompanied by two illustrative clinical cases in which neuroimaging studies played a key role in diagnosis and further management. Conclusions: Neuroimaging can be helpful in differentiating PD from both atypical and symptomatic parkinsonism. Nevertheless, extensive neurological assessment in a majority of PD cases is sufficient to make a diagnosis. A network of specialists in movement disorders should be established in order to enable better, faster and more precise diagnosis of parkinsonism.
Keywords
Parkinson’s Disease, atypical parkinsonism, neuroimaging, DaTSCAN, magnetic resonance imaging, single photon emission computed tomography
About this articleTitle
Neuroimaging in Parkinson’s Disease: necessity or exaggeration?
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
536-548
Published online
2021-10-12
Page views
7338
Article views/downloads
1827
DOI
Pubmed
Bibliographic record
Neurol Neurochir Pol 2021;55(6):536-548.
Keywords
Parkinson’s Disease
atypical parkinsonism
neuroimaging
DaTSCAN
magnetic resonance imaging
single photon emission computed tomography
Authors
Katarzyna Śmiłowska
Małgorzata Burzyńska-Makuch
Bogna Brockhuis
Radosław Piekarski
Andrzej Friedman
Aleksandra Popek
Jarosław Sławek
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