open access
Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality
- Department of Neurology, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Neurology, Krakow, Poland
- Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Pharmacology, Krakow, Poland
- John Paul II Hospital, Krakow, Poland
- Jagiellonian University Medical College, Department of Otorhinolaryngology, Krakow, Poland
- Department of Otorhinolaryngology, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Infectious and Tropical Diseases, Krakow, Poland
- Department of Infectious Diseases, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland
- Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland
- Jagiellonian University Medical College, Department of Internal Medicine and Gerontology, Krakow, Poland
- Department of Internal Medicine and Gerontology, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Immunology, Krakow, Poland
- Department of Infectious Diseases, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Infectious and Tropical Diseases, Krakow, Poland
- Jagiellonian University Medical College, Department of Internal Medicine and Gerontology, Krakow, Poland
- Department of Internal Medicine and Gerontology, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland
- Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland
- Jagiellonian University Medical College, Department of Neurology, Krakow, Poland
open access
Abstract
Objectives. To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. Material and methods. We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology. Results. During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were: fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5–88.5] vs. 63.5 [51–77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003).
Conclusions. Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality.
Abstract
Objectives. To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. Material and methods. We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology. Results. During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were: fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5–88.5] vs. 63.5 [51–77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003).
Conclusions. Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality.
Keywords
COVID-19, Sars-Cov-2 infection, Neuro-COVID-19, neurological symptoms, in-hospital mortality
Title
Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Short Communication
Pages
314-321
Published online
2021-05-13
Page views
2264
Article views/downloads
819
DOI
Pubmed
Bibliographic record
Neurol Neurochir Pol 2021;55(3):314-321.
Keywords
COVID-19
Sars-Cov-2 infection
Neuro-COVID-19
neurological symptoms
in-hospital mortality
Authors
Marcin Wnuk
Katarzyna Sawczyńska
Tomasz Kęsek
Paweł Wrona
Żaneta Chatys-Bogacka
Iwona Mazurkiewicz
Leszek Drabik
Jeremiasz Jagiełła
Joanna Szaleniec
Jacek Czepiel
Łukasz Pawliński
Artur Igor Bień
Michał Kania
Mateusz Fiema
Joanna Zięba-Parkitny
Agnes Hajek
Damian Ucieklak
Magdalena Wilk
Kamila Pośpiech
Patrycja Lechowicz
Karol Kasprzycki
Marianna Kopka
Jerzy Hohendorff
Barbara Katra
Małgorzata Kostrzycka
Michalina Adamczyk
Paulina Surowiec
Monika Rybicka
Jolanta Walczewska
Barbara Kamińska
Ewelina Piętak
Paweł Bryniarski
Monika Marona
Maciej Motyl
Alicja Kępińska-Wnuk
Małgorzata Włodarczyk
Klaudia Nowak
Elżbieta Gradek-Kwinta
Mateusz Czyżycki
Mateusz Dwojak
Agnieszka Rzemińska
Kamil Wężyk
Wojciech Koźmiński
Agnieszka Pułyk
Aleksander Garlicki
Tomasz Grodzicki
Maciej Małecki
Agnieszka Słowik
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