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miRNA-16 as a predictive factor for intracranial aneurysms in autosomal dominant polycystic kidney disease
, 1
Affiliations- Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, Poland
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Abstract
Introduction. Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic renal disorder. It leads to multiple extra-renal complications, with intracranial aneurysms (IA) among the most serious. Biological markers could become tools in identifying patients at risk of an IA. MicroRNAs 16 (miR-16) and 25 (miR-25) have been proposed as being markers of IAs in the general population. In the current study, we attempted to discover if they may also be considered markers of IAs in ADPKD. Material and methods. 64 renal transplant recipients with ADPKD were included. After magnetic resonance angiography of the brain, they were divided into a case group (IA+, n = 13) and a control group (IA-, n = 51). Expression of miRNAs in plasma was analysed by qRT-PCR.
Results. The expression of miR-16 was higher in the control (IA-) group. There was no statistically significant difference between the groups in terms of miR-25 expression.
Conclusions and clinical implications. MicroRNA-16 is a potential marker of IAs in renal transplant recipients with ADPKD. It may become a tool to identify patients who should undergo screening for an IA.
Abstract
Introduction. Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic renal disorder. It leads to multiple extra-renal complications, with intracranial aneurysms (IA) among the most serious. Biological markers could become tools in identifying patients at risk of an IA. MicroRNAs 16 (miR-16) and 25 (miR-25) have been proposed as being markers of IAs in the general population. In the current study, we attempted to discover if they may also be considered markers of IAs in ADPKD. Material and methods. 64 renal transplant recipients with ADPKD were included. After magnetic resonance angiography of the brain, they were divided into a case group (IA+, n = 13) and a control group (IA-, n = 51). Expression of miRNAs in plasma was analysed by qRT-PCR.
Results. The expression of miR-16 was higher in the control (IA-) group. There was no statistically significant difference between the groups in terms of miR-25 expression.
Conclusions and clinical implications. MicroRNA-16 is a potential marker of IAs in renal transplant recipients with ADPKD. It may become a tool to identify patients who should undergo screening for an IA.
Keywords
autosomal dominant polycystic kidney disease, biomarkers, intracranial aneurysm, kidney transplantation, micro RNA
About this articleTitle
miRNA-16 as a predictive factor for intracranial aneurysms in autosomal dominant polycystic kidney disease
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Short Communication
Pages
306-309
Published online
2021-03-30
Page views
1188
Article views/downloads
1179
DOI
Pubmed
Bibliographic record
Neurol Neurochir Pol 2021;55(3):306-309.
Keywords
autosomal dominant polycystic kidney disease
biomarkers
intracranial aneurysm
kidney transplantation
micro RNA
Authors
Andrzej Kulesza
Agnieszka Kulesza
Magda Fliszkiewicz
Anna Łabuś
Leszek Pączek
Mariusz Niemczyk
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