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open access

Vol 55, No 2 (2021)
Research Paper
Submitted: 2020-10-17
Accepted: 2020-12-14
Published online: 2021-01-25
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Prevalence of cognitive impairment in acute ischaemic stroke and use of Alberta Stroke Programme Early CT Score (ASPECTS) for early prediction of post-stroke cognitive impairment

Ahmed Esmael1, Mohammed Elsherief1, Khaled Eltoukhy1
DOI: 10.5603/PJNNS.a2021.0006
·
Pubmed: 33507530
·
Neurol Neurochir Pol 2021;55(2):179-185.
Affiliations
  1. Neurology Department, Faculty of Medicine, Mansoura University, 35516 mansoura, Egypt

open access

Vol 55, No 2 (2021)
Research papers
Submitted: 2020-10-17
Accepted: 2020-12-14
Published online: 2021-01-25

Abstract

Aim of the study. This study aims to assess the prevalence of post-stroke cognitive impairment, and to evaluate the correlation of ASPECTS with impaired cognition. Materials and methods. 150 patients presenting with acute middle cerebral artery territory ischaemic stroke were included in this study. Risk factors of ischaemic stroke and the initial NIHSS were determined. An initial and a follow-up non-contrast CT brain were carried out after seven days which were assessed by ASPECTS. The prevalence of cognitive impairment was determined by MoCA during the follow up of patients after three months. Correlations of ASPECTS, NIHSS and MoCA were done by Spearman correlation. Multivariate logistic regression analysis was carried out for the independent variables of cognitive impairment. Results. The prevalence of post-stroke cognitive impairment in this study, according to the threshold for cognitive impairment with a MoCA score of 25 or less, was 25.3% (38 patients). Significant positive correlations between ASPECTS and total MoCA test domains were found (r = 0.73 and P = 0.002). Logistic regression analysis demonstrated that the independent factors associated with cognitive impairment were older age, certain domains of the MoCA test like executive functions, memory, attention, language, NIHSS, HTN, and ASPECTS. Conclusions and clinical implications. There is a prevalence of cognitive impairment in about 25% of patients after three months of follow-up in cases with acute ischaemic stroke. ASPECTS is directly correlated with cognitive impairment, and may be considered as a biomarker of post-stroke cognitive impairment.

Abstract

Aim of the study. This study aims to assess the prevalence of post-stroke cognitive impairment, and to evaluate the correlation of ASPECTS with impaired cognition. Materials and methods. 150 patients presenting with acute middle cerebral artery territory ischaemic stroke were included in this study. Risk factors of ischaemic stroke and the initial NIHSS were determined. An initial and a follow-up non-contrast CT brain were carried out after seven days which were assessed by ASPECTS. The prevalence of cognitive impairment was determined by MoCA during the follow up of patients after three months. Correlations of ASPECTS, NIHSS and MoCA were done by Spearman correlation. Multivariate logistic regression analysis was carried out for the independent variables of cognitive impairment. Results. The prevalence of post-stroke cognitive impairment in this study, according to the threshold for cognitive impairment with a MoCA score of 25 or less, was 25.3% (38 patients). Significant positive correlations between ASPECTS and total MoCA test domains were found (r = 0.73 and P = 0.002). Logistic regression analysis demonstrated that the independent factors associated with cognitive impairment were older age, certain domains of the MoCA test like executive functions, memory, attention, language, NIHSS, HTN, and ASPECTS. Conclusions and clinical implications. There is a prevalence of cognitive impairment in about 25% of patients after three months of follow-up in cases with acute ischaemic stroke. ASPECTS is directly correlated with cognitive impairment, and may be considered as a biomarker of post-stroke cognitive impairment.

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Keywords

stroke, Alberta Stroke Programme Early CT Score, National Institutes of Health Stroke Scale, cognitive impairment

About this article
Title

Prevalence of cognitive impairment in acute ischaemic stroke and use of Alberta Stroke Programme Early CT Score (ASPECTS) for early prediction of post-stroke cognitive impairment

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 55, No 2 (2021)

Article type

Research Paper

Pages

179-185

Published online

2021-01-25

Page views

2053

Article views/downloads

936

DOI

10.5603/PJNNS.a2021.0006

Pubmed

33507530

Bibliographic record

Neurol Neurochir Pol 2021;55(2):179-185.

Keywords

stroke
Alberta Stroke Programme Early CT Score
National Institutes of Health Stroke Scale
cognitive impairment

Authors

Ahmed Esmael
Mohammed Elsherief
Khaled Eltoukhy

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