Vol 55, No 1 (2021)
Research Paper
Published online: 2020-12-14
Submitted: 2020-09-18
Accepted: 2020-12-02
Get Citation

Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)

Piotr Alster, Natalia Madetko, Andrzej Friedman
DOI: 10.5603/PJNNS.a2020.0097
·
Pubmed: 33315235
·
Neurol Neurochir Pol 2021;55(1):97-101.

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Vol 55, No 1 (2021)
Research papers
Published online: 2020-12-14
Submitted: 2020-09-18
Accepted: 2020-12-02

Abstract

Aim of the study. To examine possible features of neuroinflammation in progressive supranuclear palsy — Richardson syndrome and corticobasal syndrome (CBS).

Clinical rationale for the study. Neutrophil-to-lymphocyte ratio (NLR) is a parameter reflecting inflammation used in numerous branches of medicine. The search for pathogenesis of the diseases partly related to inflammatory processes confirms the need to obtain possible factors which could be relatively easily verified. NLR is a benchmark routinely evaluated in most hospitalised patients.

Materials and methods. 23 patients with a clinical diagnosis of PSP-RS, 18 patients with CBS, and 32 healthy controls, were included in the study. Blood samples were assessed in the context of neutrophil and lymphocyte rates. Subsequently, the results were transformed into neutrophil-to-lymphocyte ratio (NLR). The NLRs from each group were statistically assessed using a Kruskal-Wallis test and post-hoc analysis.

Results. Statistical analysis confirmed significant differences in NLR between PSP-RS and control group. No other significant differences were observed.

Clinical implications. The possible use of NLR in the additional examination of atypical parkinsonisms.

Conclusions. To the best of our knowledge, this is the first study comparing this aspect of neuroinflammation in PSP and CBS. It presents NLR as a promising non-specific parameter in neurodegenerative diseases.

Abstract

Aim of the study. To examine possible features of neuroinflammation in progressive supranuclear palsy — Richardson syndrome and corticobasal syndrome (CBS).

Clinical rationale for the study. Neutrophil-to-lymphocyte ratio (NLR) is a parameter reflecting inflammation used in numerous branches of medicine. The search for pathogenesis of the diseases partly related to inflammatory processes confirms the need to obtain possible factors which could be relatively easily verified. NLR is a benchmark routinely evaluated in most hospitalised patients.

Materials and methods. 23 patients with a clinical diagnosis of PSP-RS, 18 patients with CBS, and 32 healthy controls, were included in the study. Blood samples were assessed in the context of neutrophil and lymphocyte rates. Subsequently, the results were transformed into neutrophil-to-lymphocyte ratio (NLR). The NLRs from each group were statistically assessed using a Kruskal-Wallis test and post-hoc analysis.

Results. Statistical analysis confirmed significant differences in NLR between PSP-RS and control group. No other significant differences were observed.

Clinical implications. The possible use of NLR in the additional examination of atypical parkinsonisms.

Conclusions. To the best of our knowledge, this is the first study comparing this aspect of neuroinflammation in PSP and CBS. It presents NLR as a promising non-specific parameter in neurodegenerative diseases.

Get Citation

Keywords

progressive supranuclear palsy, PSP, corticobasal degeneration, CBS, NLR

About this article
Title

Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 55, No 1 (2021)

Article type

Research Paper

Pages

97-101

Published online

2020-12-14

DOI

10.5603/PJNNS.a2020.0097

Pubmed

33315235

Bibliographic record

Neurol Neurochir Pol 2021;55(1):97-101.

Keywords

progressive supranuclear palsy
PSP
corticobasal degeneration
CBS
NLR

Authors

Piotr Alster
Natalia Madetko
Andrzej Friedman

References (20)
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