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Altered functional brain imaging in migraine patients: BOLD preliminary study in migraine with and without aura
Affiliations- Department of Neurology, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80, 01-802 Warsaw, Poland
- Bioimaging Research Center, World Hearing Center, The Institute of Physiology and Pathology of Hearing, Kajetany, Poland
- Faculty of Humanities, Nicolaus Copernicus University, Toruń, Poland
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Abstract
Design. Migraine is regarded as a complex brain dysfunction of sensory and modulatory networks with the secondary sensitisation of the trigeminal system as well as the affected brain area’s activities. The particular role of the hippocampus and the brainstem in the first phase of the attack, the disrupted cognitive network, and the activation of the limbic and visual systems, are the main discoveries in the field of migraine imaging that have been achieved using functional techniques. Thus advanced neuroimaging has been widely employed to study the pathogenesis of migraine. Objective. The evaluation of fMRI BOLD images of migraine patients with or without aura, with particular attention to the interictal phase. Subjects and Methods. The aim of this study was to compare brain activity during visual stimuli by fMRI BOLD in the interictal phase (black and white checkerboard tests, static or flickering) of 16 migraine patients, eight with aura and eight without. Results. We demonstrated differences in the right part of the brainstem, the left part of the cerebellum, and in the right middle temporal gyrus. However, the bilateral brain activation in the occipital and frontal lobe remained similar. Conclusions. Results of our preliminary study suggest that migraine with aura and migraine without aura might be separate disorders, and this requires further investigation.
Abstract
Design. Migraine is regarded as a complex brain dysfunction of sensory and modulatory networks with the secondary sensitisation of the trigeminal system as well as the affected brain area’s activities. The particular role of the hippocampus and the brainstem in the first phase of the attack, the disrupted cognitive network, and the activation of the limbic and visual systems, are the main discoveries in the field of migraine imaging that have been achieved using functional techniques. Thus advanced neuroimaging has been widely employed to study the pathogenesis of migraine. Objective. The evaluation of fMRI BOLD images of migraine patients with or without aura, with particular attention to the interictal phase. Subjects and Methods. The aim of this study was to compare brain activity during visual stimuli by fMRI BOLD in the interictal phase (black and white checkerboard tests, static or flickering) of 16 migraine patients, eight with aura and eight without. Results. We demonstrated differences in the right part of the brainstem, the left part of the cerebellum, and in the right middle temporal gyrus. However, the bilateral brain activation in the occipital and frontal lobe remained similar. Conclusions. Results of our preliminary study suggest that migraine with aura and migraine without aura might be separate disorders, and this requires further investigation.
Keywords
migraine, fMRI, BOLD MRI, trigeminovascular system
About this articleTitle
Altered functional brain imaging in migraine patients: BOLD preliminary study in migraine with and without aura
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Research Paper
Pages
304-310
Published online
2019-08-22
Page views
1857
Article views/downloads
384
DOI
Pubmed
Bibliographic record
Neurol Neurochir Pol 2019;53(4):304-310.
Keywords
migraine
fMRI
BOLD MRI
trigeminovascular system
Authors
Paweł Kreczmański
Tomasz Wolak
Monika Lewandowska
Izabela Domitrz
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