Vol 53, No 4 (2019)
Short communication
Published online: 2019-08-19
Submitted: 2019-01-28
Accepted: 2019-06-21
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The symptoms asymmetry of drug-induced parkinsonism is not related to nigrostriatal cell degeneration: a SPECT-DaTSCAN study

Agata Gajos, Janusz Dąbrowski, Małgorzata Bieńkiewicz, Anna Płachcińska, Jacek Kuśmierek, Andrzej Bogucki
DOI: 10.5603/PJNNS.a2019.0031
·
Pubmed: 31441498
·
Neurol Neurochir Pol 2019;53(4):311-314.

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Vol 53, No 4 (2019)
Short communication
Published online: 2019-08-19
Submitted: 2019-01-28
Accepted: 2019-06-21

Abstract

Aim. Drug-induced parkinsonism (DIP) is the most common form of parkinsonism after Parkinson’s disease (PD) itself. It has been widely believed that DIP is characterised by symmetry of symptoms. Studies of patients with DIP in whom PD had been ruled out by SPECT-DaTSCAN have shown that symptom asymmetry is a common element of DIP clinical presentation. The aim of our study was to determine whether the asymmetry of symptoms in DIP is related to any abnormality within the presynaptic part of the nigrostriatal dopaminergic system.

Materials and methods. Eleven patients with the diagnosis of DIP and asymmetric symptoms were studied. Their individual SPECT-DaTSCANs were normal. Indices calculated for the whole group of radiotracer uptake in the whole striatum, putamen and caudate contralateral to more severe DIP symptoms were compared to values obtained in the opposite hemisphere.

Results. We did not find significant differences in radiotracer uptake in structures contralateral to more severe clinical symptoms when compared to the homolateral hemisphere.

Conclusions. Our results have not confirmed the presence of a presynaptic nigrostriatal deficit which could be related to asymmetry of DIP. The factors responsible for the asymmetry of DIP symptoms should be sought in the postsynaptic part of the nigrostriatal dopaminergic system.

Abstract

Aim. Drug-induced parkinsonism (DIP) is the most common form of parkinsonism after Parkinson’s disease (PD) itself. It has been widely believed that DIP is characterised by symmetry of symptoms. Studies of patients with DIP in whom PD had been ruled out by SPECT-DaTSCAN have shown that symptom asymmetry is a common element of DIP clinical presentation. The aim of our study was to determine whether the asymmetry of symptoms in DIP is related to any abnormality within the presynaptic part of the nigrostriatal dopaminergic system.

Materials and methods. Eleven patients with the diagnosis of DIP and asymmetric symptoms were studied. Their individual SPECT-DaTSCANs were normal. Indices calculated for the whole group of radiotracer uptake in the whole striatum, putamen and caudate contralateral to more severe DIP symptoms were compared to values obtained in the opposite hemisphere.

Results. We did not find significant differences in radiotracer uptake in structures contralateral to more severe clinical symptoms when compared to the homolateral hemisphere.

Conclusions. Our results have not confirmed the presence of a presynaptic nigrostriatal deficit which could be related to asymmetry of DIP. The factors responsible for the asymmetry of DIP symptoms should be sought in the postsynaptic part of the nigrostriatal dopaminergic system.

Get Citation

Keywords

drug-induced parkinsonism, asymmetry of symptoms, presynaptic nigrostriatal deficit, SPECT-DaTSCAN

About this article
Title

The symptoms asymmetry of drug-induced parkinsonism is not related to nigrostriatal cell degeneration: a SPECT-DaTSCAN study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 4 (2019)

Pages

311-314

Published online

2019-08-19

DOI

10.5603/PJNNS.a2019.0031

Pubmed

31441498

Bibliographic record

Neurol Neurochir Pol 2019;53(4):311-314.

Keywords

drug-induced parkinsonism
asymmetry of symptoms
presynaptic nigrostriatal deficit
SPECT-DaTSCAN

Authors

Agata Gajos
Janusz Dąbrowski
Małgorzata Bieńkiewicz
Anna Płachcińska
Jacek Kuśmierek
Andrzej Bogucki

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