Vol 53, No 4 (2019)
Research paper
Published online: 2019-07-25
Submitted: 2019-02-22
Accepted: 2019-06-22
Get Citation

Assessment of the relationship between platelet reactivity, vascular risk factors and gender in cerebral ischaemia patients

Adam Wiśniewski, Joanna Sikora, Karolina Filipska, Grzegorz Kozera
DOI: 10.5603/PJNNS.a2019.0028
·
Pubmed: 31343071
·
Neurol Neurochir Pol 2019;53(4):258-264.

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Vol 53, No 4 (2019)
Research paper
Published online: 2019-07-25
Submitted: 2019-02-22
Accepted: 2019-06-22

Abstract

Aim. Excessive activation and platelet aggregation play important roles in the aetiopathogenesis of cerebral ischaemia. The aim of this study was to assess the relationship between platelet reactivity, gender and vascular risk factors in cerebral ischaemia patients.

Clinical rationale for the study. The research is useful because we found high risk groups of inefficient aspirin treatment in cerebral ischaemia patients.

Material and methods. The study involved 101 patients, including 69 patients with ischaemic stroke and 32 patients with transient ischaemic attack. The assessment of platelet reactivity was made within 24 hours of the disease onset using two aggregometric methods: impedance and optical.

Results. Resistance to acetylsalicylic acid among people with cerebral ischaemia was estimated at 30.69% using impedance aggregometry and 9.2% using optical aggregometry. There were no differences in platelet reactivity or ASA resistance between the groups of patients with stroke and TIA in either method. In the whole group of patients (p = 0.04), and in the group of patients with stroke (p = 0.0143), higher reactivity of platelets was observed by impedance aggregometry in men than in women. In the whole group of patients (p = 0.0229), and in the subgroup with stroke (p = 0.0123), it was shown that aspirin resistance is significantly more common in the subgroup of men than in women. In patients suffering from nicotine addiction, significantly higher platelet reactivity was found in the whole group of patients (p = 0.004), as well as in the subgroup of patients with stroke (p = 0.0135).

Conclusions. There are no differences between platelet reactivity and the incidence of aspirin resistance in patients with stroke and TIA. Male gender and smoking are associated with greater reactivity of platelets and more frequent occurrence of acetylsalicylic acid resistance in patients with cerebral ischaemia.

Clinical implications. Dual antiplatelet therapy or clopidogrel treatment should be considered in smoking males with cerebral ischaemia due to the high risk of aspirin inefficiency.

Abstract

Aim. Excessive activation and platelet aggregation play important roles in the aetiopathogenesis of cerebral ischaemia. The aim of this study was to assess the relationship between platelet reactivity, gender and vascular risk factors in cerebral ischaemia patients.

Clinical rationale for the study. The research is useful because we found high risk groups of inefficient aspirin treatment in cerebral ischaemia patients.

Material and methods. The study involved 101 patients, including 69 patients with ischaemic stroke and 32 patients with transient ischaemic attack. The assessment of platelet reactivity was made within 24 hours of the disease onset using two aggregometric methods: impedance and optical.

Results. Resistance to acetylsalicylic acid among people with cerebral ischaemia was estimated at 30.69% using impedance aggregometry and 9.2% using optical aggregometry. There were no differences in platelet reactivity or ASA resistance between the groups of patients with stroke and TIA in either method. In the whole group of patients (p = 0.04), and in the group of patients with stroke (p = 0.0143), higher reactivity of platelets was observed by impedance aggregometry in men than in women. In the whole group of patients (p = 0.0229), and in the subgroup with stroke (p = 0.0123), it was shown that aspirin resistance is significantly more common in the subgroup of men than in women. In patients suffering from nicotine addiction, significantly higher platelet reactivity was found in the whole group of patients (p = 0.004), as well as in the subgroup of patients with stroke (p = 0.0135).

Conclusions. There are no differences between platelet reactivity and the incidence of aspirin resistance in patients with stroke and TIA. Male gender and smoking are associated with greater reactivity of platelets and more frequent occurrence of acetylsalicylic acid resistance in patients with cerebral ischaemia.

Clinical implications. Dual antiplatelet therapy or clopidogrel treatment should be considered in smoking males with cerebral ischaemia due to the high risk of aspirin inefficiency.

Get Citation

Keywords

platelet reactivity, stroke, aspirin resistance, gender, risk factors

About this article
Title

Assessment of the relationship between platelet reactivity, vascular risk factors and gender in cerebral ischaemia patients

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 4 (2019)

Pages

258-264

Published online

2019-07-25

DOI

10.5603/PJNNS.a2019.0028

Pubmed

31343071

Bibliographic record

Neurol Neurochir Pol 2019;53(4):258-264.

Keywords

platelet reactivity
stroke
aspirin resistance
gender
risk factors

Authors

Adam Wiśniewski
Joanna Sikora
Karolina Filipska
Grzegorz Kozera

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