open access

Vol 53, No 1 (2019)
Research papers
Published online: 2019-01-07
Submitted: 2018-12-06
Accepted: 2018-12-06
Get Citation

Familial occurrence of carpal tunnel syndrome

Piotr Puchalski, Zbigniew Szlosser, Andrzej Żyluk
DOI: 10.5603/PJNNS.a2019.0004
·
Pubmed: 30620043
·
Neurol Neurochir Pol 2019;53(1):43-46.

open access

Vol 53, No 1 (2019)
Research papers
Published online: 2019-01-07
Submitted: 2018-12-06
Accepted: 2018-12-06

Abstract

The objective of this study was to investigate the incidence of familial carpal tunnel syndrome in patients admitted to the
authors’ institution for carpal tunnel release. Questionnaires completed by 120 patients: 92 women (77%) and 28 men (23%) at a mean age of 56 years at their baseline clinical examination were reviewed. Familial occurrence of the disease was noted in 21 patients (17%): 16 women and five men. Three family members were affected in three patients, two relatives in eight patients, and one relative in 10 patients, giving a total of 35 affected relatives. The patients’ sisters (n = 16) were the most commonly involved, followed by mothers (n = 12), daughters (n = 2), brothers (n = 2), grandmothers (n = 2) and an aunt (n = 1). Bilateral manifestation of the disease was noted in 19 patients (90%) and in 31 (88%) of their affected relatives. The results suggest that carpal tunnel syndrome shows a moderate tendency to familial occurrence and, if so, it usually manifests bilaterally.

Abstract

The objective of this study was to investigate the incidence of familial carpal tunnel syndrome in patients admitted to the
authors’ institution for carpal tunnel release. Questionnaires completed by 120 patients: 92 women (77%) and 28 men (23%) at a mean age of 56 years at their baseline clinical examination were reviewed. Familial occurrence of the disease was noted in 21 patients (17%): 16 women and five men. Three family members were affected in three patients, two relatives in eight patients, and one relative in 10 patients, giving a total of 35 affected relatives. The patients’ sisters (n = 16) were the most commonly involved, followed by mothers (n = 12), daughters (n = 2), brothers (n = 2), grandmothers (n = 2) and an aunt (n = 1). Bilateral manifestation of the disease was noted in 19 patients (90%) and in 31 (88%) of their affected relatives. The results suggest that carpal tunnel syndrome shows a moderate tendency to familial occurrence and, if so, it usually manifests bilaterally.

Get Citation

Keywords

carpal tunnel syndrome, inheritable traits, familial predispositions, bilateral presentation

About this article
Title

Familial occurrence of carpal tunnel syndrome

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 1 (2019)

Pages

43-46

Published online

2019-01-07

DOI

10.5603/PJNNS.a2019.0004

Pubmed

30620043

Bibliographic record

Neurol Neurochir Pol 2019;53(1):43-46.

Keywords

carpal tunnel syndrome
inheritable traits
familial predispositions
bilateral presentation

Authors

Piotr Puchalski
Zbigniew Szlosser
Andrzej Żyluk

References (17)
  1. TANZER RC. The carpal-tunnel syndrome; a clinical and anatomical study. J Bone Joint Surg Am. 1959; 41-A(4): 626–634.
  2. Phalen GS. Reflections on 21 years' experience with the carpal-tunnel syndrome. JAMA. 1970; 212(8): 1365–1367.
  3. Radecki P. The familial occurrence of carpal tunnel syndrome. Muscle Nerve. 1994; 17(3): 325–330.
  4. Gossett JG, Chance PF. Is there a familial carpal tunnel syndrome? An evaluation and literature review. Muscle Nerve. 1998; 21(11): 1533–1536.
  5. Atroshi I, Gummesson C, Ornstein E, et al. Prevalence of carpal tunnel syndrome in a general population. JAMA. 1999; 282(2): 153–158.
  6. Padua L, Coraci D, Erra C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016; 15(12): 1273–1284.
  7. Alford JW, Weiss APC, Akelman E. The familial incidence of carpal tunnel syndrome in patients with unilateral and bilateral disease. Am J Orthop (Belle Mead NJ). 2004; 33(8): 397–400.
  8. Żyluk A, Dąbal L, Szlosser Z. Constitutional factors and predisposition to carpal tunnel syndrome. Pol Orthop Traumatol. 2011; 76: 127–132.
  9. Leifer D, Cros D, Halperin JJ, et al. Familial bilateral carpal tunnel syndrome: report of two families. Arch Phys Med Rehabil. 1992; 73(4): 393–397.
  10. Murakami T, Tachibana S, Endo Y, et al. Familial carpal tunnel syndrome due to amyloidogenic transthyretin His 114 variant. Neurology. 1994; 44(2): 315–318.
  11. Ihara Y, Nobukuni K, Namba R, et al. A family of familial hypercholesterolemia with cerebral infarction and without coronary heart disease. An unusual case with corneal opacity, polyneuropathy and carpal tunnel syndrome in the family: therapy with probucol and tocopherol nicotinate. J Neurol Sci. 1991; 106(1): 10–18.
  12. Michaud LJ, Hays RM, Dudgeon BJ, et al. Congenital carpal tunnel syndrome: case report of autosomal dominant inheritance and review of the literature. Arch Phys Med Rehabil. 1990; 71(6): 430–432.
  13. Iannicelli E, Chianta GA, Salvini V, et al. Evaluation of bifid median nerve with sonography and MR imaging. J Ultrasound Med. 2000; 19(7): 481–485.
  14. Mahjneh I, Saarinen A, Siivola J. Familial carpal tunnel syndrome: a report of a Finnish family. Acta Neurol Scand. 2001; 104(6): 377–379.
  15. Dada S, Burger MC, Massij F, et al. Carpal tunnel syndrome: The role of collagen gene variants. Gene. 2016; 587(1): 53–58.
  16. Burger MC, De Wet H, Collins M. Matrix metalloproteinase genes on chromosome 11q22 and risk of carpal tunnel syndrome. Rheumatol Int. 2016; 36(3): 413–419.
  17. Kim JK, Koh YDo, Kim JS, et al. Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome. J Orthop Res. 2010; 28(11): 1463–1468.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl