open access

Vol 53, No 1 (2019)
Research papers
Published online: 2019-01-04
Submitted: 2018-11-19
Accepted: 2018-11-19
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Prevalence and extent of right-to-left shunt on contrast-enhanced transcranial Doppler in patients with chronic hyperventilation syndrome: results of a case-control study

Jacek Staszewski, Kazimierz Tomczykiewicz, Anna Piusińska-Macoch, Adam Stępień
DOI: 10.5603/PJNNS.a2019.0003
·
Pubmed: 30614514
·
Neurol Neurochir Pol 2019;53(1):90-94.

open access

Vol 53, No 1 (2019)
Research papers
Published online: 2019-01-04
Submitted: 2018-11-19
Accepted: 2018-11-19

Abstract

Aim. Chronic hyperventilation syndrome (CHVS) represents a frequent but poorly understood breathing pattern disorder. In a previous small pilot study, we reported a higher prevalence of right-to-left shunt (RLS) in CHVS patients than in healthy

subjects. The aim of this study was to confirm those previous results from this larger and matched case-control study, and to evaluate the prevalence and grade of RLS in patients with CHVS in whom organic and psychiatric causes were excluded.

Clinical rationale for the study. Determining other types of CHVS triggers not related to organic or psychiatric causes which could be clinically useful.

Material and methods. 100 subjects (mean age 34 ± 6 years; 80% females), including 50 patients with CHVS and 50 age- and sex-matched healthy controls (CG), were prospectively recruited into this single-centre study. Vascular RLS was diagnosed using contrast-enhanced transcranial Doppler (c-TCD).

Results. RLS prevalence significantly increased in the CHVS group (n = 23) compared to the CG group (n = 8) (46% vs 16%; p < 0.01). Patients with CHVS and RLS tended to have more frequent permanent shunts compared to the CG (60% vs 25%; p = 0.08), but there was no difference regarding RLS grading between the groups.

Conclusions and clinical implications. This study confirmed our previous findings in which the prevalence of RLS in patients with CHVS was significantly higher than in an age- and sex-matched healthy control group. However, we could not confirm the

results of our prior study, where RLS was larger in CHVS than in CG. The tentative association between RLS and CHVS needs to be further examined.

Abstract

Aim. Chronic hyperventilation syndrome (CHVS) represents a frequent but poorly understood breathing pattern disorder. In a previous small pilot study, we reported a higher prevalence of right-to-left shunt (RLS) in CHVS patients than in healthy

subjects. The aim of this study was to confirm those previous results from this larger and matched case-control study, and to evaluate the prevalence and grade of RLS in patients with CHVS in whom organic and psychiatric causes were excluded.

Clinical rationale for the study. Determining other types of CHVS triggers not related to organic or psychiatric causes which could be clinically useful.

Material and methods. 100 subjects (mean age 34 ± 6 years; 80% females), including 50 patients with CHVS and 50 age- and sex-matched healthy controls (CG), were prospectively recruited into this single-centre study. Vascular RLS was diagnosed using contrast-enhanced transcranial Doppler (c-TCD).

Results. RLS prevalence significantly increased in the CHVS group (n = 23) compared to the CG group (n = 8) (46% vs 16%; p < 0.01). Patients with CHVS and RLS tended to have more frequent permanent shunts compared to the CG (60% vs 25%; p = 0.08), but there was no difference regarding RLS grading between the groups.

Conclusions and clinical implications. This study confirmed our previous findings in which the prevalence of RLS in patients with CHVS was significantly higher than in an age- and sex-matched healthy control group. However, we could not confirm the

results of our prior study, where RLS was larger in CHVS than in CG. The tentative association between RLS and CHVS needs to be further examined.

Get Citation

Keywords

chronic hyperventilation syndrome, right-to-left shunt, transcranial Doppler

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About this article
Title

Prevalence and extent of right-to-left shunt on contrast-enhanced transcranial Doppler in patients with chronic hyperventilation syndrome: results of a case-control study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 1 (2019)

Pages

90-94

Published online

2019-01-04

DOI

10.5603/PJNNS.a2019.0003

Pubmed

30614514

Bibliographic record

Neurol Neurochir Pol 2019;53(1):90-94.

Keywords

chronic hyperventilation syndrome
right-to-left shunt
transcranial Doppler

Authors

Jacek Staszewski
Kazimierz Tomczykiewicz
Anna Piusińska-Macoch
Adam Stępień

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