open access

Vol 53, No 1 (2019)
Invited review article
Published online: 2019-01-07
Submitted: 2018-11-06
Accepted: 2018-11-06
Get Citation

A systematic review of Gamma-aminobutyric Acid Receptor Type B autoimmunity

Jake H. McKay, Elliot L. Dimberg, Alfonso S. Lopez Chiriboga
DOI: 10.5603/PJNNS.a2018.0005
·
Pubmed: 30620044
·
Neurol Neurochir Pol 2019;53(1):1-7.

open access

Vol 53, No 1 (2019)
Invited review article
Published online: 2019-01-07
Submitted: 2018-11-06
Accepted: 2018-11-06

Abstract

Objective. To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies.

Methods. Literature was reviewed on PubMed, Mendeley literature search, and the American Academy of Neurology database for articles published from June 2008 to October of 2018 using a variety of key words. These key words include: „gamma-aminobutyric acid seizures,” „gamma-aminobutyric acid limbic encephalitis”, „GABA(B) receptor antibodies,” „autoimmune encephalitis,” „autoimmune epilepsy,” „GABA(B) encephalitis, „ and “GABA paraneoplastic.” With the results, the papers were reviewed in a systematic manner.

Results. A total of 10 studies were reviewed. A summary of the demographic, clinical, and serological findings of the cases detailed in the literature are provided. An additional illustrative case is described. In total, 94 patients were reviewed.

Conclusions. GABAB-R autoimmune disease is characterized by refractory seizures or status epilepticus and frequent association with small cell lung cancer. Additionally, a substantial minority of patients have non-inflammatory CSF.

Abstract

Objective. To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies.

Methods. Literature was reviewed on PubMed, Mendeley literature search, and the American Academy of Neurology database for articles published from June 2008 to October of 2018 using a variety of key words. These key words include: „gamma-aminobutyric acid seizures,” „gamma-aminobutyric acid limbic encephalitis”, „GABA(B) receptor antibodies,” „autoimmune encephalitis,” „autoimmune epilepsy,” „GABA(B) encephalitis, „ and “GABA paraneoplastic.” With the results, the papers were reviewed in a systematic manner.

Results. A total of 10 studies were reviewed. A summary of the demographic, clinical, and serological findings of the cases detailed in the literature are provided. An additional illustrative case is described. In total, 94 patients were reviewed.

Conclusions. GABAB-R autoimmune disease is characterized by refractory seizures or status epilepticus and frequent association with small cell lung cancer. Additionally, a substantial minority of patients have non-inflammatory CSF.

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Keywords

Gamma-aminobutyric acid seizures, gamma-aminobutyric acid receptor type B, GABA(B) receptor antibodies, autoimmune encephalitis, autoimmune epilepsy, GABA-B encephalitis, GABA limbic encephalitis, GABA paraneoplastic

About this article
Title

A systematic review of Gamma-aminobutyric Acid Receptor Type B autoimmunity

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 1 (2019)

Pages

1-7

Published online

2019-01-07

DOI

10.5603/PJNNS.a2018.0005

Pubmed

30620044

Bibliographic record

Neurol Neurochir Pol 2019;53(1):1-7.

Keywords

Gamma-aminobutyric acid seizures
gamma-aminobutyric acid receptor type B
GABA(B) receptor antibodies
autoimmune encephalitis
autoimmune epilepsy
GABA-B encephalitis
GABA limbic encephalitis
GABA paraneoplastic

Authors

Jake H. McKay
Elliot L. Dimberg
Alfonso S. Lopez Chiriboga

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