open access

Vol 53, No 4 (2019)
Invited editorial
Submitted: 2019-08-30
Accepted: 2019-08-30
Get Citation

Treatment with istradefylline for postural abnormalities in Parkinson’s disease

Angela B. Deutschländer
DOI: 10.5603/PJNNS.2019.0038
·
Pubmed: 31469906
·
Neurol Neurochir Pol 2019;53(4):239-241.

open access

Vol 53, No 4 (2019)
Invited editorial
Submitted: 2019-08-30
Accepted: 2019-08-30

Abstract

Introduction. In the current edition, Fujioka and colleagues report on four Japanese patients with Parkinson disease (PD) and severe postural abnormalities treated with istradefylline (adenosine A2A receptor antagonist); further, dopamine agonists were with- drawn. Three patients experienced significant improvements of postural abnormalities. Clinical reflections. Postural abnormalities in PD include camptocormia, antecollis, lateral trunk flexion, and scoliosis. They may be very pronounced and significantly reduce quality of life. The therapy of postural deformities in PD is currently disappointing. Clinical implications. Effective therapeutic strategies for postural deformities in PD are an unmet need. Larger clinical trials investigating novel approaches including istradefylline are warranted.

Abstract

Introduction. In the current edition, Fujioka and colleagues report on four Japanese patients with Parkinson disease (PD) and severe postural abnormalities treated with istradefylline (adenosine A2A receptor antagonist); further, dopamine agonists were with- drawn. Three patients experienced significant improvements of postural abnormalities. Clinical reflections. Postural abnormalities in PD include camptocormia, antecollis, lateral trunk flexion, and scoliosis. They may be very pronounced and significantly reduce quality of life. The therapy of postural deformities in PD is currently disappointing. Clinical implications. Effective therapeutic strategies for postural deformities in PD are an unmet need. Larger clinical trials investigating novel approaches including istradefylline are warranted.

Get Citation
About this article
Title

Treatment with istradefylline for postural abnormalities in Parkinson’s disease

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 53, No 4 (2019)

Pages

239-241

DOI

10.5603/PJNNS.2019.0038

Pubmed

31469906

Bibliographic record

Neurol Neurochir Pol 2019;53(4):239-241.

Authors

Angela B. Deutschländer

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