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Research Paper
Submitted: 2023-10-31
Accepted: 2024-01-10
Published online: 2024-03-19
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Immunological alterations in intracranial aneurysm: a prospective study on selected biomarker profiles in blood collected during endovascular neurointervention

Krzysztof Bartnik1, Jarosław Żyłkowski1, Jakub Giziński1, Remigiusz Krysiak1, Urszula Wilkowojska2, Damian Strzemecki3, Tomasz P. Rygiel4, Przemysław Kunert5, Magdalena Januszewicz1
DOI: 10.5603/pjnns.98061
·
Pubmed: 38501555
Affiliations
  1. Second Department of Radiology, Medical University of Warsaw, Warsaw, Poland
  2. Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
  3. Department of Experimental Pharmacology, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
  4. Laboratory of Immunology, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
  5. Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland

open access

Ahead of print
Research papers
Submitted: 2023-10-31
Accepted: 2024-01-10
Published online: 2024-03-19

Abstract

Introduction. Previous studies showed that the concentrations of selected chemokines are locally elevated in samples collected from the lumen of intracranial aneurysms (IA). Our objective was to determine whether the observed differences in analyte concentrations were influenced by the origin of the blood samples (i.e. cerebral versus peripheral), thus providing insight into the localised nature of these alterations and their significance in IA pathogenesis.

Material and methods. This prospective study included 24 patients with IA who underwent endovascular embolisation. Concentrations of selected analytes were analysed in blood samples from the IA lumen, feeding artery, and aorta. The analytes included MPO, Lipocalin-2/NGAL, sICAM-1, sVCAM-1, and serum amyloid A.

Results. Higher median plasma concentrations of MPO, lipocalin-2/NGAL, sVCAM-1, and SAA were found in samples obtained from the IA lumen and the feeding artery compared to the aorta. The concentration of sICAM-1 was significantly higher in the IA compared to the aorta, but did not differ between the proximal artery and the aorta. No significant differences in any analyte concentration were observed between the IA and the proximal artery.

Conclusions. These findings suggest that the IA and the proximal vessel share similarities in the local immunological environment, which is different from that observed in the aorta. Further studies are needed to fully understand and elucidate these observations.

Abstract

Introduction. Previous studies showed that the concentrations of selected chemokines are locally elevated in samples collected from the lumen of intracranial aneurysms (IA). Our objective was to determine whether the observed differences in analyte concentrations were influenced by the origin of the blood samples (i.e. cerebral versus peripheral), thus providing insight into the localised nature of these alterations and their significance in IA pathogenesis.

Material and methods. This prospective study included 24 patients with IA who underwent endovascular embolisation. Concentrations of selected analytes were analysed in blood samples from the IA lumen, feeding artery, and aorta. The analytes included MPO, Lipocalin-2/NGAL, sICAM-1, sVCAM-1, and serum amyloid A.

Results. Higher median plasma concentrations of MPO, lipocalin-2/NGAL, sVCAM-1, and SAA were found in samples obtained from the IA lumen and the feeding artery compared to the aorta. The concentration of sICAM-1 was significantly higher in the IA compared to the aorta, but did not differ between the proximal artery and the aorta. No significant differences in any analyte concentration were observed between the IA and the proximal artery.

Conclusions. These findings suggest that the IA and the proximal vessel share similarities in the local immunological environment, which is different from that observed in the aorta. Further studies are needed to fully understand and elucidate these observations.

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Keywords

intracranial aneurysm, immunology, biomarker profile, endovascular treatment, local microenvironment

About this article
Title

Immunological alterations in intracranial aneurysm: a prospective study on selected biomarker profiles in blood collected during endovascular neurointervention

Journal

Neurologia i Neurochirurgia Polska

Issue

Ahead of print

Article type

Research Paper

Published online

2024-03-19

Page views

177

Article views/downloads

106

DOI

10.5603/pjnns.98061

Pubmed

38501555

Keywords

intracranial aneurysm
immunology
biomarker profile
endovascular treatment
local microenvironment

Authors

Krzysztof Bartnik
Jarosław Żyłkowski
Jakub Giziński
Remigiusz Krysiak
Urszula Wilkowojska
Damian Strzemecki
Tomasz P. Rygiel
Przemysław Kunert
Magdalena Januszewicz

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