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Submitted: 2023-10-09
Accepted: 2024-03-12
Published online: 2024-04-25
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Predicting haemorrhagic transformation through serum biochemical indices for patients after endovascular treatment: a retrospective study

Fang Wu12, Qingyuan Wu1234, Qinji Zhou1234, Lina Zhang123, Fei Yan23, Yaping Xiao25, Fanping Meng26, Lei He12, Zhenjie Yang27, Chuyue Wu1234
DOI: 10.5603/pjnns.97759
·
Pubmed: 38662104
Affiliations
  1. Department of Neurology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China
  2. School of Medicine, Chongqing University, Chongqing, China
  3. Chongqing Municipality Clinical Research Centre for Geriatric Diseases, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China
  4. NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  5. Department of Pharmacy, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China
  6. Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China
  7. Department of Radiology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China

open access

Ahead of print
Research papers
Submitted: 2023-10-09
Accepted: 2024-03-12
Published online: 2024-04-25

Abstract

Introduction. The aim of this study was to determine the serum biochemical markers that can predict the risk of haemorrhagic transformation (HT) before and after endovascular treatment (EVT). Material and methods. This study included patients with anterior circulation large vessel occlusion (ACLVO) who underwent EVT within six hours of symptom onset between September 2017 and September 2022. These patients were retrospectively categorised into two groups: an HT group and a No-HT group. Results. A total of 180 patients were included in the study, of whom 55 (30.6%) had HT. The monocyte count before EVT (p = = 0.005, OR = 0.694, 95% CI 0.536–0.898), the activated partial thromboplastin time before EVT (p = 0.009, OR = 0.186, 95% CI 0.699–0.952), and the eosinophil count after EVT (p = 0.038, OR = 0.001, 95% CI 0.000–0.018) were all found to be independent predictors of HT, with warning values of 6.65%, 22.95 seconds, and 0.035*10^9/L, respectively. When compared to prediction using only demographic data [AUC = 0.662,95% CI (0.545, 0.780)], adding biochemical indices before EVT [AUC = 0.719,95% CI (0.617, 0.821)], adding biochemical indices after EVT [AUC = 0.670,95% CI (0.566, 0.773)], and adding both [AUC = 0.778,95% CI (0.686, 0.870)], the prediction efficiency of HT was improved among all three combinations, with no statistical significance. Conclusions. The levels of serum biochemical markers were found to show significant changes before and after EVT in ACLVO patients. A combination of demographic data and serum biochemical markers proved to be effective in predicting the occurrence of HT in patients with ACLVO who underwent EVT.

Abstract

Introduction. The aim of this study was to determine the serum biochemical markers that can predict the risk of haemorrhagic transformation (HT) before and after endovascular treatment (EVT). Material and methods. This study included patients with anterior circulation large vessel occlusion (ACLVO) who underwent EVT within six hours of symptom onset between September 2017 and September 2022. These patients were retrospectively categorised into two groups: an HT group and a No-HT group. Results. A total of 180 patients were included in the study, of whom 55 (30.6%) had HT. The monocyte count before EVT (p = = 0.005, OR = 0.694, 95% CI 0.536–0.898), the activated partial thromboplastin time before EVT (p = 0.009, OR = 0.186, 95% CI 0.699–0.952), and the eosinophil count after EVT (p = 0.038, OR = 0.001, 95% CI 0.000–0.018) were all found to be independent predictors of HT, with warning values of 6.65%, 22.95 seconds, and 0.035*10^9/L, respectively. When compared to prediction using only demographic data [AUC = 0.662,95% CI (0.545, 0.780)], adding biochemical indices before EVT [AUC = 0.719,95% CI (0.617, 0.821)], adding biochemical indices after EVT [AUC = 0.670,95% CI (0.566, 0.773)], and adding both [AUC = 0.778,95% CI (0.686, 0.870)], the prediction efficiency of HT was improved among all three combinations, with no statistical significance. Conclusions. The levels of serum biochemical markers were found to show significant changes before and after EVT in ACLVO patients. A combination of demographic data and serum biochemical markers proved to be effective in predicting the occurrence of HT in patients with ACLVO who underwent EVT.

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Keywords

anterior circulation large vessel occlusion, endovascular treatment, haemorrhagic transformation, serum biochemical markers

About this article
Title

Predicting haemorrhagic transformation through serum biochemical indices for patients after endovascular treatment: a retrospective study

Journal

Neurologia i Neurochirurgia Polska

Issue

Ahead of print

Article type

Research Paper

Published online

2024-04-25

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57

Article views/downloads

37

DOI

10.5603/pjnns.97759

Pubmed

38662104

Keywords

anterior circulation large vessel occlusion
endovascular treatment
haemorrhagic transformation
serum biochemical markers

Authors

Fang Wu
Qingyuan Wu
Qinji Zhou
Lina Zhang
Fei Yan
Yaping Xiao
Fanping Meng
Lei He
Zhenjie Yang
Chuyue Wu

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