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Middle temporal gyrus approach to mesial temporal lobe tumours in children
, 1, 13, 1
Affiliations- Department of Neurosurgery, Children's Memorial Health Institute, Warsaw, Poland
- Department of Neurosurgery, Dpartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, Poland
- Department of Descriptive and Clinical Anatomy, Biostructure Centre, Medical University of Warsaw, Warsaw, Poland
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Abstract
Aim of the study. To assess whether the middle temporal gyrus (MTG) approach to mesial temporal lobe (MTL) tumours is an effective procedure for the treatment of epilepsy in children.
Clinical rationale for the study. MTL tumours are a common cause of drug-resistant epilepsy in children. There is as yet no consensus regarding their treatment. One possibility is resection via a MTG approach.
Material and methods. We assessed the medical records of patients treated at the Department of Neurosurgery, Children’s Memorial Health Institute,Warsaw, Poland between 2002 and 2020. A prospectively maintained database including clinical, laboratory, and radiographic presentation, as well as pre- and post-operative course, was analysed. Patients with at least a one- -year follow-up were included.
Results. There were 14 patients aged 4–18 years who underwent a MTG approach for a MTL tumour. All presented with epileptic seizure, and none had neurological deficit on admission to hospital. Median follow-up was 2.5 years. Neuronavigation was used to adjust the approach, localise the temporal horn, and achieve radical resection of the tumour and the hippocampus. Gross total resection was performed in all cases. In most patients, histopathological examination revealed ganglioglioma. One patient had transient aphasia. Two patients developed hemiparesis after surgery, which later improved. One of them also experienced visual disturbances. Acute complications were more frequent in younger patients (p = 0.024). In all cases, MRI confirmed complete resection and there was no tumour recurrence during the follow-up period. 13/14 patients remained seizure-free (Engel class I).
Conclusions and clinical implications. The MTG approach to MTL tumours is an effective procedure for the treatment of epilepsy in children. It avoids removal of the lateral temporal lobe and poses only a minor risk of permanent neurological complications.
Abstract
Aim of the study. To assess whether the middle temporal gyrus (MTG) approach to mesial temporal lobe (MTL) tumours is an effective procedure for the treatment of epilepsy in children.
Clinical rationale for the study. MTL tumours are a common cause of drug-resistant epilepsy in children. There is as yet no consensus regarding their treatment. One possibility is resection via a MTG approach.
Material and methods. We assessed the medical records of patients treated at the Department of Neurosurgery, Children’s Memorial Health Institute,Warsaw, Poland between 2002 and 2020. A prospectively maintained database including clinical, laboratory, and radiographic presentation, as well as pre- and post-operative course, was analysed. Patients with at least a one- -year follow-up were included.
Results. There were 14 patients aged 4–18 years who underwent a MTG approach for a MTL tumour. All presented with epileptic seizure, and none had neurological deficit on admission to hospital. Median follow-up was 2.5 years. Neuronavigation was used to adjust the approach, localise the temporal horn, and achieve radical resection of the tumour and the hippocampus. Gross total resection was performed in all cases. In most patients, histopathological examination revealed ganglioglioma. One patient had transient aphasia. Two patients developed hemiparesis after surgery, which later improved. One of them also experienced visual disturbances. Acute complications were more frequent in younger patients (p = 0.024). In all cases, MRI confirmed complete resection and there was no tumour recurrence during the follow-up period. 13/14 patients remained seizure-free (Engel class I).
Conclusions and clinical implications. The MTG approach to MTL tumours is an effective procedure for the treatment of epilepsy in children. It avoids removal of the lateral temporal lobe and poses only a minor risk of permanent neurological complications.
Keywords
middle temporal gyrus, mesial temporal lobe, epilepsy surgery, seizure-free outcome, children
About this articleTitle
Middle temporal gyrus approach to mesial temporal lobe tumours in children
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Research Paper
Published online
2024-02-23
Page views
185
Article views/downloads
134
DOI
Pubmed
Keywords
middle temporal gyrus
mesial temporal lobe
epilepsy surgery
seizure-free outcome
children
Authors
Paweł Kowalczyk
Ernest J. Bobeff
Wojciech Nowak
Maciej K Ciołkowski
Marcin Roszkowski
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