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open access

Vol 55, No 3 (2021)
Short Communication
Submitted: 2020-12-31
Accepted: 2021-04-13
Published online: 2021-05-13
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Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality

Marcin Wnuk12, Katarzyna Sawczyńska2, Tomasz Kęsek3, Paweł Wrona3, Żaneta Chatys-Bogacka2, Iwona Mazurkiewicz3, Leszek Drabik45, Jeremiasz Jagiełła2, Joanna Szaleniec67, Jacek Czepiel89, Łukasz Pawliński310, Artur Igor Bień311, Michał Kania311, Mateusz Fiema311, Joanna Zięba-Parkitny311, Agnes Hajek311, Damian Ucieklak311, Magdalena Wilk311, Kamila Pośpiech311, Patrycja Lechowicz311, Karol Kasprzycki311, Marianna Kopka311, Jerzy Hohendorff311, Barbara Katra311, Małgorzata Kostrzycka311, Michalina Adamczyk311, Paulina Surowiec311, Monika Rybicka1213, Jolanta Walczewska1213, Barbara Kamińska1213, Ewelina Piętak1213, Paweł Bryniarski121314, Monika Marona21, Maciej Motyl1, Alicja Kępińska-Wnuk21, Małgorzata Włodarczyk1, Klaudia Nowak21, Elżbieta Gradek-Kwinta1, Mateusz Czyżycki1, Mateusz Dwojak1, Agnieszka Rzemińska1, Kamil Wężyk1, Wojciech Koźmiński1, Agnieszka Pułyk1, Aleksander Garlicki1516, Tomasz Grodzicki1718, Maciej Małecki1920, Agnieszka Słowik121
DOI: 10.5603/PJNNS.a2021.0039
·
Pubmed: 34037979
·
Neurol Neurochir Pol 2021;55(3):314-321.
Affiliations
  1. Department of Neurology, University Hospital in Krakow, Poland
  2. Jagiellonian University Medical College, Department of Neurology, Krakow, Poland
  3. Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland
  4. Jagiellonian University Medical College, Department of Pharmacology, Krakow, Poland
  5. John Paul II Hospital, Krakow, Poland
  6. Jagiellonian University Medical College, Department of Otorhinolaryngology, Krakow, Poland
  7. Department of Otorhinolaryngology, University Hospital in Krakow, Poland
  8. Jagiellonian University Medical College, Department of Infectious and Tropical Diseases, Krakow, Poland
  9. Department of Infectious Diseases, University Hospital in Krakow, Poland
  10. Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland
  11. Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland
  12. Jagiellonian University Medical College, Department of Internal Medicine and Gerontology, Krakow, Poland
  13. Department of Internal Medicine and Gerontology, University Hospital in Krakow, Poland
  14. Jagiellonian University Medical College, Department of Immunology, Krakow, Poland
  15. Department of Infectious Diseases, University Hospital in Krakow, Poland
  16. Jagiellonian University Medical College, Department of Infectious and Tropical Diseases, Krakow, Poland
  17. Jagiellonian University Medical College, Department of Internal Medicine and Gerontology, Krakow, Poland
  18. Department of Internal Medicine and Gerontology, University Hospital in Krakow, Poland
  19. Jagiellonian University Medical College, Department of Metabolic Diseases and Diabetology, Krakow, Poland
  20. Department of Metabolic Diseases and Diabetology, University Hospital in Krakow, Poland
  21. Jagiellonian University Medical College, Department of Neurology, Krakow, Poland

open access

Vol 55, No 3 (2021)
Short communications
Submitted: 2020-12-31
Accepted: 2021-04-13
Published online: 2021-05-13

Abstract

Objectives. To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. Material and methods. We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology. Results. During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were: fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5–88.5] vs. 63.5 [51–77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003).

Conclusions. Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality.

Abstract

Objectives. To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. Material and methods. We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology. Results. During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were: fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5–88.5] vs. 63.5 [51–77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003).

Conclusions. Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality.

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Keywords

COVID-19, Sars-Cov-2 infection, Neuro-COVID-19, neurological symptoms, in-hospital mortality

About this article
Title

Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 55, No 3 (2021)

Article type

Short Communication

Pages

314-321

Published online

2021-05-13

Page views

2261

Article views/downloads

818

DOI

10.5603/PJNNS.a2021.0039

Pubmed

34037979

Bibliographic record

Neurol Neurochir Pol 2021;55(3):314-321.

Keywords

COVID-19
Sars-Cov-2 infection
Neuro-COVID-19
neurological symptoms
in-hospital mortality

Authors

Marcin Wnuk
Katarzyna Sawczyńska
Tomasz Kęsek
Paweł Wrona
Żaneta Chatys-Bogacka
Iwona Mazurkiewicz
Leszek Drabik
Jeremiasz Jagiełła
Joanna Szaleniec
Jacek Czepiel
Łukasz Pawliński
Artur Igor Bień
Michał Kania
Mateusz Fiema
Joanna Zięba-Parkitny
Agnes Hajek
Damian Ucieklak
Magdalena Wilk
Kamila Pośpiech
Patrycja Lechowicz
Karol Kasprzycki
Marianna Kopka
Jerzy Hohendorff
Barbara Katra
Małgorzata Kostrzycka
Michalina Adamczyk
Paulina Surowiec
Monika Rybicka
Jolanta Walczewska
Barbara Kamińska
Ewelina Piętak
Paweł Bryniarski
Monika Marona
Maciej Motyl
Alicja Kępińska-Wnuk
Małgorzata Włodarczyk
Klaudia Nowak
Elżbieta Gradek-Kwinta
Mateusz Czyżycki
Mateusz Dwojak
Agnieszka Rzemińska
Kamil Wężyk
Wojciech Koźmiński
Agnieszka Pułyk
Aleksander Garlicki
Tomasz Grodzicki
Maciej Małecki
Agnieszka Słowik

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