open access

Vol 52, No 6 (2018)
Review articles
Submitted: 2019-11-05
Accepted: 2019-11-05
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Isoprostanes as potential cerebral vasospasm biomarkers

Karol Wiśniewski, Jagoda Jóźwik-Pruska, Michał Bieńkowski, Ernest J. Bobeff, Maciej Bryl, Joanna Kałużna-Czaplińska, Dariusz J. Jaskólski
Pubmed: 30314904
·
Neurol Neurochir Pol 2018;52(6):643-651.

open access

Vol 52, No 6 (2018)
Review articles
Submitted: 2019-11-05
Accepted: 2019-11-05

Abstract

Despite enormous progress in medicine, symptomatic cerebral vasospasm (CVS), remains an unexplained clinical problem, which leaves both physicians and patients helpless and relying on chance, due to the lack of specific marker indicative of imminent danger as well as the lack of specific treatment. In our opinion CVS occurrence depends on dynamic disbalance between free radicals' formation (oxidative stress) and antioxidant activity. Isoprostanes are products of free-radical peroxidation of polyunsaturated fatty acids, and seem to mark a promising path for the research aiming to unravel its possible mechanism. Not only are they the biomarkers of oxidative stress in vivo and in vitro, but also have manifold biological effects (including vasoactive, inflammatory and mitogenic) via activation of the thromboxane A2 receptor (TBXA2R), both in physiological and pathophysiological processes. This review addresses the importance of isoprostanes in CVS in quest of appropriate biomarkers.

Abstract

Despite enormous progress in medicine, symptomatic cerebral vasospasm (CVS), remains an unexplained clinical problem, which leaves both physicians and patients helpless and relying on chance, due to the lack of specific marker indicative of imminent danger as well as the lack of specific treatment. In our opinion CVS occurrence depends on dynamic disbalance between free radicals' formation (oxidative stress) and antioxidant activity. Isoprostanes are products of free-radical peroxidation of polyunsaturated fatty acids, and seem to mark a promising path for the research aiming to unravel its possible mechanism. Not only are they the biomarkers of oxidative stress in vivo and in vitro, but also have manifold biological effects (including vasoactive, inflammatory and mitogenic) via activation of the thromboxane A2 receptor (TBXA2R), both in physiological and pathophysiological processes. This review addresses the importance of isoprostanes in CVS in quest of appropriate biomarkers.

Get Citation

Keywords

Isoprostanes Oxidative stress Redox signalling Cerebral vasospasm Aneurysmal subarachnoid haemorrhage

About this article
Title

Isoprostanes as potential cerebral vasospasm biomarkers

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 6 (2018)

Pages

643-651

Pubmed

30314904

Bibliographic record

Neurol Neurochir Pol 2018;52(6):643-651.

Keywords

Isoprostanes Oxidative stress Redox signalling Cerebral vasospasm Aneurysmal subarachnoid haemorrhage

Authors

Karol Wiśniewski
Jagoda Jóźwik-Pruska
Michał Bieńkowski
Ernest J. Bobeff
Maciej Bryl
Joanna Kałużna-Czaplińska
Dariusz J. Jaskólski

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