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Isoprostanes as potential cerebral vasospasm biomarkers
open access
Abstract
Despite enormous progress in medicine, symptomatic cerebral vasospasm (CVS), remains an unexplained clinical problem, which leaves both physicians and patients helpless and relying on chance, due to the lack of specific marker indicative of imminent danger as well as the lack of specific treatment. In our opinion CVS occurrence depends on dynamic disbalance between free radicals' formation (oxidative stress) and antioxidant activity. Isoprostanes are products of free-radical peroxidation of polyunsaturated fatty acids, and seem to mark a promising path for the research aiming to unravel its possible mechanism. Not only are they the biomarkers of oxidative stress in vivo and in vitro, but also have manifold biological effects (including vasoactive, inflammatory and mitogenic) via activation of the thromboxane A2 receptor (TBXA2R), both in physiological and pathophysiological processes. This review addresses the importance of isoprostanes in CVS in quest of appropriate biomarkers.
Abstract
Despite enormous progress in medicine, symptomatic cerebral vasospasm (CVS), remains an unexplained clinical problem, which leaves both physicians and patients helpless and relying on chance, due to the lack of specific marker indicative of imminent danger as well as the lack of specific treatment. In our opinion CVS occurrence depends on dynamic disbalance between free radicals' formation (oxidative stress) and antioxidant activity. Isoprostanes are products of free-radical peroxidation of polyunsaturated fatty acids, and seem to mark a promising path for the research aiming to unravel its possible mechanism. Not only are they the biomarkers of oxidative stress in vivo and in vitro, but also have manifold biological effects (including vasoactive, inflammatory and mitogenic) via activation of the thromboxane A2 receptor (TBXA2R), both in physiological and pathophysiological processes. This review addresses the importance of isoprostanes in CVS in quest of appropriate biomarkers.
Keywords
Isoprostanes Oxidative stress Redox signalling Cerebral vasospasm Aneurysmal subarachnoid haemorrhage
About this articleTitle
Isoprostanes as potential cerebral vasospasm biomarkers
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
643-651
Published online
2019-11-05
Page views
389
Article views/downloads
438
Pubmed
Bibliographic record
Neurol Neurochir Pol 2018;52(6):643-651.
Keywords
Isoprostanes Oxidative stress Redox signalling Cerebral vasospasm Aneurysmal subarachnoid haemorrhage
Authors
Karol Wiśniewski
Jagoda Jóźwik-Pruska
Michał Bieńkowski
Ernest J. Bobeff
Maciej Bryl
Joanna Kałużna-Czaplińska
Dariusz J. Jaskólski
