open access

Vol 52, No 5 (2018)
Original research articles
Submitted: 2018-01-29
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sP- and sE-selectin in stroke patients with metabolic disorders

Malgorzata Pawelczyk, Andrzej Glabiński, Beata Kaczorowska, Zbigniew Baj
DOI: 10.1016/j.pjnns.2018.08.004
·
Neurol Neurochir Pol 2018;52(5):599-605.

open access

Vol 52, No 5 (2018)
Original research articles
Submitted: 2018-01-29

Abstract

Background

Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders.

The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke.

Material and methods

The study group consisted of 84 patients with acute non-lacunar ischemic stroke divided into four subgroups with: (1) normolipidemia and normoglycemia, (2) normolipidemia and hyperglycemia, (3) hyperlipidemia and normoglycemia, (4) hyperlipidemia and hyperglycemia. 21 healthy subjects served as controls. We analyzed the concentration of adhesion molecules sP-selectin and sE-selectin in serum collected from all studied groups using ELISA method.

Results

We observed significantly higher sE- and sP-selectin concentration in patients with hyperglycemia and hyperlipidemia compared to both control subjects and patients with normolipidemia and normoglycemia. We did not observe additional effect of comorbid hyperlipidemia and hyperglycemia on studied markers. Soluble E- and P-selectin concentration correlated positively with LDL, TC and HbA1c level in all stroke patients.

Conclusion

Soluble E- and P-selectin, blood markers of vascular injury and platelet activation, could be useful in the assessment of atherothrombotic properties of hyperglycemia and hyperlipidemia in stroke patients.

Abstract

Background

Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders.

The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke.

Material and methods

The study group consisted of 84 patients with acute non-lacunar ischemic stroke divided into four subgroups with: (1) normolipidemia and normoglycemia, (2) normolipidemia and hyperglycemia, (3) hyperlipidemia and normoglycemia, (4) hyperlipidemia and hyperglycemia. 21 healthy subjects served as controls. We analyzed the concentration of adhesion molecules sP-selectin and sE-selectin in serum collected from all studied groups using ELISA method.

Results

We observed significantly higher sE- and sP-selectin concentration in patients with hyperglycemia and hyperlipidemia compared to both control subjects and patients with normolipidemia and normoglycemia. We did not observe additional effect of comorbid hyperlipidemia and hyperglycemia on studied markers. Soluble E- and P-selectin concentration correlated positively with LDL, TC and HbA1c level in all stroke patients.

Conclusion

Soluble E- and P-selectin, blood markers of vascular injury and platelet activation, could be useful in the assessment of atherothrombotic properties of hyperglycemia and hyperlipidemia in stroke patients.

Get Citation

Keywords

Soluble P-selectin, Soluble E-selectin, Hyperlipidemia, Hyperglycemia, Ischemic stroke

About this article
Title

sP- and sE-selectin in stroke patients with metabolic disorders

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 5 (2018)

Pages

599-605

DOI

10.1016/j.pjnns.2018.08.004

Bibliographic record

Neurol Neurochir Pol 2018;52(5):599-605.

Keywords

Soluble P-selectin
Soluble E-selectin
Hyperlipidemia
Hyperglycemia
Ischemic stroke

Authors

Malgorzata Pawelczyk
Andrzej Glabiński
Beata Kaczorowska
Zbigniew Baj

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