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sP- and sE-selectin in stroke patients with metabolic disorders
Affiliations- Department of Neurology and Stroke, Medical University of Lodz, Lodz, Poland
- Department of Pathophysiology and Clinical Immunology, Medical University of Lodz, Plac Hallera 1, Lodz, Poland
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Abstract
Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders.
The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke.
Material and methodsThe study group consisted of 84 patients with acute non-lacunar ischemic stroke divided into four subgroups with: (1) normolipidemia and normoglycemia, (2) normolipidemia and hyperglycemia, (3) hyperlipidemia and normoglycemia, (4) hyperlipidemia and hyperglycemia. 21 healthy subjects served as controls. We analyzed the concentration of adhesion molecules sP-selectin and sE-selectin in serum collected from all studied groups using ELISA method.
ResultsWe observed significantly higher sE- and sP-selectin concentration in patients with hyperglycemia and hyperlipidemia compared to both control subjects and patients with normolipidemia and normoglycemia. We did not observe additional effect of comorbid hyperlipidemia and hyperglycemia on studied markers. Soluble E- and P-selectin concentration correlated positively with LDL, TC and HbA1c level in all stroke patients.
ConclusionSoluble E- and P-selectin, blood markers of vascular injury and platelet activation, could be useful in the assessment of atherothrombotic properties of hyperglycemia and hyperlipidemia in stroke patients.
Abstract
Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders.
The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke.
Material and methodsThe study group consisted of 84 patients with acute non-lacunar ischemic stroke divided into four subgroups with: (1) normolipidemia and normoglycemia, (2) normolipidemia and hyperglycemia, (3) hyperlipidemia and normoglycemia, (4) hyperlipidemia and hyperglycemia. 21 healthy subjects served as controls. We analyzed the concentration of adhesion molecules sP-selectin and sE-selectin in serum collected from all studied groups using ELISA method.
ResultsWe observed significantly higher sE- and sP-selectin concentration in patients with hyperglycemia and hyperlipidemia compared to both control subjects and patients with normolipidemia and normoglycemia. We did not observe additional effect of comorbid hyperlipidemia and hyperglycemia on studied markers. Soluble E- and P-selectin concentration correlated positively with LDL, TC and HbA1c level in all stroke patients.
ConclusionSoluble E- and P-selectin, blood markers of vascular injury and platelet activation, could be useful in the assessment of atherothrombotic properties of hyperglycemia and hyperlipidemia in stroke patients.
Keywords
Soluble P-selectin, Soluble E-selectin, Hyperlipidemia, Hyperglycemia, Ischemic stroke
About this articleTitle
sP- and sE-selectin in stroke patients with metabolic disorders
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
599-605
Published online
2018-08-17
Page views
323
Article views/downloads
735
DOI
10.1016/j.pjnns.2018.08.004
Bibliographic record
Neurol Neurochir Pol 2018;52(5):599-605.
Keywords
Soluble P-selectin
Soluble E-selectin
Hyperlipidemia
Hyperglycemia
Ischemic stroke
Authors
Malgorzata Pawelczyk
Andrzej Glabiński
Beata Kaczorowska
Zbigniew Baj
