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The impact of subthalamic deep brain stimulation on polysomnographic sleep pattern in patients with Parkinson's disease – Preliminary report
Affiliations- Neurology Department, St Adalbert Hospital Copernicus PL, Gdansk, Poland
- Neurological and Psychiatric Nursing Department, Medical University of Gdansk, Gdansk, Poland
- Adult Psychiatry Clinic, Medical University of Gdansk, Gdansk, Poland
- Neurosurgery Department, Copernicus PL, Gdansk, Poland
- Department of Nuclear Medicine, Medical University of Gdańsk, Gdansk, Poland
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Abstract
We present the preliminary results of the study focused on the impact of subthalamic deep brain stimulation (DBS-STN) on sleep and other non-motor symptoms (NMS).
Materials and methodsTen patients with advanced PD, underwent two-night polysomnography (PSG) mean 1.1 week before surgery and 6.2 months post DBS programming. NMS were assessed with a set of scales before surgery and 6 months and 12 months following DBS programming.
ResultsContrary to previous studies, we noted deterioration of sleep pattern in the follow-up PSG. We found a decrease in total sleep time, duration of the stage N2, with prolongation of stage N1 and wakefulness after sleep onset. We did not detect any impact of DBS-STN on subjective severity of restless legs syndrome. REM – sleep behavior disorder, however reported was not observed in any patient during PSG evaluations. We also found statistically significant correlations between severity of sleep disturbances and quality of life, as well as, between severity of motor symptoms and worse objective sleep quality.
ConclusionsWe found that DBS-STN improved quality of life, subjective quality of sleep and sleepiness, however, contrary to the previous studies the objective parameters of sleep worsened after the surgery.
Abstract
We present the preliminary results of the study focused on the impact of subthalamic deep brain stimulation (DBS-STN) on sleep and other non-motor symptoms (NMS).
Materials and methodsTen patients with advanced PD, underwent two-night polysomnography (PSG) mean 1.1 week before surgery and 6.2 months post DBS programming. NMS were assessed with a set of scales before surgery and 6 months and 12 months following DBS programming.
ResultsContrary to previous studies, we noted deterioration of sleep pattern in the follow-up PSG. We found a decrease in total sleep time, duration of the stage N2, with prolongation of stage N1 and wakefulness after sleep onset. We did not detect any impact of DBS-STN on subjective severity of restless legs syndrome. REM – sleep behavior disorder, however reported was not observed in any patient during PSG evaluations. We also found statistically significant correlations between severity of sleep disturbances and quality of life, as well as, between severity of motor symptoms and worse objective sleep quality.
ConclusionsWe found that DBS-STN improved quality of life, subjective quality of sleep and sleepiness, however, contrary to the previous studies the objective parameters of sleep worsened after the surgery.
Keywords
Parkinson' s disease, Deep brain stimulation, Sleep, Quality of life, Polysomnography
About this articleTitle
The impact of subthalamic deep brain stimulation on polysomnographic sleep pattern in patients with Parkinson's disease – Preliminary report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
514-518
Published online
2018-06-01
Page views
609
Article views/downloads
377
DOI
10.1016/j.pjnns.2018.05.006
Bibliographic record
Neurol Neurochir Pol 2018;52(4):514-518.
Keywords
Parkinson's disease
Deep brain stimulation
Sleep
Quality of life
Polysomnography
Authors
Jarosław Dulski
Michał Schinwelski
Agnieszka Konkel
Karol Grabowski
Witold Libionka
Piotr Wąż
Sitek E.J.
Jarosław Sławek
