open access

Vol 52, No 4 (2018)
Original research articles
Submitted: 2017-12-25
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The evaluation of the effects of steroid treatment on the tumor and peritumoral edema by DWI and MR spectroscopy in brain tumors

Cahit Kural, Gokce Kaan Atac, Ozkan Tehli, Ilker Solmaz, Caglar Temiz, Irgen Hodaj, Yusuf Izci
DOI: 10.1016/j.pjnns.2018.03.002
·
Neurol Neurochir Pol 2018;52(4):495-504.

open access

Vol 52, No 4 (2018)
Original research articles
Submitted: 2017-12-25

Abstract

Objective

To investigate the effects of dexamethasone on brain tumor and peritumoral edema by different sequences of magnetic resonance imaging (MRI).

Materials and methods

MRI was performed in 28 patients with brain tumor. Patients were divided into the 3 groups based on the histological diagnosis; Group I: high-grade glial tumor, Group II: low-grade glial tumor, and Group III: brain metastasis. The measurements of peritumoral edema volume and apparent diffusion coefficient (ADC) values were performed while the peak areas of cerebral metabolites were measured by spectroscopy in groups I and II. The changes in edema volumes, ADC values and cholin/creatine peak areas were compared.

Results

The volume of peritumoral edema was decreased in groups I and II, but increased in group III after dexamethasone treatment. These changes were not statistically significant for 3 groups. ADC value was decreased in group I and increased in groups II and III. Changes in ADC values were statistically significant. Cholin/creatine peak areas were decreased after dexamethasone in groups I and II, but these changes were also not significant.

Conclusion

Dexamethasone has no significant effect on the volume of peritumoral edema in glial tumor and metastasis. Moreover, dexamethasone increases the fluid movements in low grade gliomas and metastases, decreases in high grade gliomas. However, more comprehensive clinical studies are needed to show the effects of dexamethasone on brain tumors and peritumoral edema.

Abstract

Objective

To investigate the effects of dexamethasone on brain tumor and peritumoral edema by different sequences of magnetic resonance imaging (MRI).

Materials and methods

MRI was performed in 28 patients with brain tumor. Patients were divided into the 3 groups based on the histological diagnosis; Group I: high-grade glial tumor, Group II: low-grade glial tumor, and Group III: brain metastasis. The measurements of peritumoral edema volume and apparent diffusion coefficient (ADC) values were performed while the peak areas of cerebral metabolites were measured by spectroscopy in groups I and II. The changes in edema volumes, ADC values and cholin/creatine peak areas were compared.

Results

The volume of peritumoral edema was decreased in groups I and II, but increased in group III after dexamethasone treatment. These changes were not statistically significant for 3 groups. ADC value was decreased in group I and increased in groups II and III. Changes in ADC values were statistically significant. Cholin/creatine peak areas were decreased after dexamethasone in groups I and II, but these changes were also not significant.

Conclusion

Dexamethasone has no significant effect on the volume of peritumoral edema in glial tumor and metastasis. Moreover, dexamethasone increases the fluid movements in low grade gliomas and metastases, decreases in high grade gliomas. However, more comprehensive clinical studies are needed to show the effects of dexamethasone on brain tumors and peritumoral edema.

Get Citation

Keywords

Glioma, Metastasis, Steroid, Diffusion weighted image, Spectroscopy

About this article
Title

The evaluation of the effects of steroid treatment on the tumor and peritumoral edema by DWI and MR spectroscopy in brain tumors

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 4 (2018)

Pages

495-504

DOI

10.1016/j.pjnns.2018.03.002

Bibliographic record

Neurol Neurochir Pol 2018;52(4):495-504.

Keywords

Glioma
Metastasis
Steroid
Diffusion weighted image
Spectroscopy

Authors

Cahit Kural
Gokce Kaan Atac
Ozkan Tehli
Ilker Solmaz
Caglar Temiz
Irgen Hodaj
Yusuf Izci

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