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Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes
Affiliations- Department of Neurology, Medical University of Warsaw, 8 Kondratowicza str, 03-242 Warsaw, Poland
- Brodno Mazovian Hospital, Poland
- Department of Nuclear Medicine, Medical University of Warsaw, Poland
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Abstract
Corticobasal Degeneration Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) are types of four repeats (4R) tauopathies, which are associated to parkinsonian syndromes. The aim of the work is to analyze cases of patients of the Department of Neurology, overlapping of syndromes related to both pathologies and to show that most likely CBS and PSP are not lineary related to their commonly associated syndromes i.e. adequately corticobasal syndromes and progressive supranuclear palsy syndromes. In the context of each patient factors in favor of most likely CBS, PSP or both diseases are discussed and analyzed using contemporary criteria. This work discusses multidimensional aspect of the examination of five patient aged 64 to 83 – 4 females and 1 male with 4R tauopathies and difficulties in distinguishing both diseases. The duration of the disease varied from 1 to 5 years. Each patient after neurological examination was assessed using magnetic resonance imaging (MRI) and psychological test. Examination of all patients was extended using single photon emission computer tomography (SPECT) to reveal the usefulness of this tool in differentiation of diseases was done. The outcome of this examination was verified with prior clinical manifestation of patients and morphological abnormalities in magnetic resonance imaging. Autopsies were not conducted.
Abstract
Corticobasal Degeneration Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) are types of four repeats (4R) tauopathies, which are associated to parkinsonian syndromes. The aim of the work is to analyze cases of patients of the Department of Neurology, overlapping of syndromes related to both pathologies and to show that most likely CBS and PSP are not lineary related to their commonly associated syndromes i.e. adequately corticobasal syndromes and progressive supranuclear palsy syndromes. In the context of each patient factors in favor of most likely CBS, PSP or both diseases are discussed and analyzed using contemporary criteria. This work discusses multidimensional aspect of the examination of five patient aged 64 to 83 – 4 females and 1 male with 4R tauopathies and difficulties in distinguishing both diseases. The duration of the disease varied from 1 to 5 years. Each patient after neurological examination was assessed using magnetic resonance imaging (MRI) and psychological test. Examination of all patients was extended using single photon emission computer tomography (SPECT) to reveal the usefulness of this tool in differentiation of diseases was done. The outcome of this examination was verified with prior clinical manifestation of patients and morphological abnormalities in magnetic resonance imaging. Autopsies were not conducted.
Keywords
Tauopathy, Atypical parkinsonism, PSP, CBD, CBS
About this articleTitle
Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
459-464
Published online
2018-07-03
Page views
441
Article views/downloads
766
DOI
10.1016/j.pjnns.2018.06.002
Bibliographic record
Neurol Neurochir Pol 2018;52(4):459-464.
Keywords
Tauopathy
Atypical parkinsonism
PSP
CBD
CBS
Authors
Piotr Alster
Ewa Krzyżanowska
Dariusz Koziorowski
Stanisław Szlufik
Dorota Różański
Joanna Noskowska
Justyna Mianowicz
Adrian Michno
Leszek Królicki
Andrzej Friedman
