open access

Vol 52, No 3 (2018)
Original research articles
Submitted: 2017-08-30
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Cerebral vasomotor reactivity predicts the development of acute stroke in patients with internal carotid artery stenosis

Keju Ju, Lingling Zhong, Xiaoyu Ni, Hua Cao, Guanliang Cheng, Lianshu Ding
DOI: 10.1016/j.pjnns.2017.12.015
·
Neurol Neurochir Pol 2018;52(3):374-378.

open access

Vol 52, No 3 (2018)
Original research articles
Submitted: 2017-08-30

Abstract

Objective

To investigate the relationship between cerebral vasomotor reactivity (VMR) and acute stroke in patients with internal carotid artery stenosis.

Methods

54 patients with internal carotid artery stenosis were enrolled. VMR was calculated by transcranial Doppler monitoring of the velocity of blood flow. 3-Dimensional dynamic contrast enhanced magnetic resonance angiography was used to detect stenosis, and diffusion weighted imaging was used to detect infarction.

Results

VMR value was significantly lower in patients with carotid artery stenosis than in control group (T=3.112, P=0.002), and significantly lower in patients with aortic atherosclerotic stroke than in non-infarct group (T=10.930, P=0.000). However, VMR value was significantly higher in patients with new-onset small-artery occlusion stroke than in non-infarction group (T=−2.538, P=0.013). Scatter plots showed that aortic atherosclerotic stroke occurred mainly in patients with severe internal carotid artery stenosis, and VMR value in cerebral artery significantly decreased.

Conclusion

Decreased VMR value is an important prognostic factor for the occurrence of aortic atherosclerotic stroke, and can be used as a reference for preoperative hemodynamic evaluation in patients with internal carotid artery stenosis.

Abstract

Objective

To investigate the relationship between cerebral vasomotor reactivity (VMR) and acute stroke in patients with internal carotid artery stenosis.

Methods

54 patients with internal carotid artery stenosis were enrolled. VMR was calculated by transcranial Doppler monitoring of the velocity of blood flow. 3-Dimensional dynamic contrast enhanced magnetic resonance angiography was used to detect stenosis, and diffusion weighted imaging was used to detect infarction.

Results

VMR value was significantly lower in patients with carotid artery stenosis than in control group (T=3.112, P=0.002), and significantly lower in patients with aortic atherosclerotic stroke than in non-infarct group (T=10.930, P=0.000). However, VMR value was significantly higher in patients with new-onset small-artery occlusion stroke than in non-infarction group (T=−2.538, P=0.013). Scatter plots showed that aortic atherosclerotic stroke occurred mainly in patients with severe internal carotid artery stenosis, and VMR value in cerebral artery significantly decreased.

Conclusion

Decreased VMR value is an important prognostic factor for the occurrence of aortic atherosclerotic stroke, and can be used as a reference for preoperative hemodynamic evaluation in patients with internal carotid artery stenosis.

Get Citation

Keywords

Vasomotor reactivity, Transcranial Doppler, Carotid artery stenosis, Cerebral infarction, Stroke

About this article
Title

Cerebral vasomotor reactivity predicts the development of acute stroke in patients with internal carotid artery stenosis

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 3 (2018)

Pages

374-378

DOI

10.1016/j.pjnns.2017.12.015

Bibliographic record

Neurol Neurochir Pol 2018;52(3):374-378.

Keywords

Vasomotor reactivity
Transcranial Doppler
Carotid artery stenosis
Cerebral infarction
Stroke

Authors

Keju Ju
Lingling Zhong
Xiaoyu Ni
Hua Cao
Guanliang Cheng
Lianshu Ding

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