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Cerebral vasomotor reactivity predicts the development of acute stroke in patients with internal carotid artery stenosis
Affiliations- Department of Neurology, Huai’an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai’an, China
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Abstract
To investigate the relationship between cerebral vasomotor reactivity (VMR) and acute stroke in patients with internal carotid artery stenosis.
Methods54 patients with internal carotid artery stenosis were enrolled. VMR was calculated by transcranial Doppler monitoring of the velocity of blood flow. 3-Dimensional dynamic contrast enhanced magnetic resonance angiography was used to detect stenosis, and diffusion weighted imaging was used to detect infarction.
ResultsVMR value was significantly lower in patients with carotid artery stenosis than in control group (T=3.112, P=0.002), and significantly lower in patients with aortic atherosclerotic stroke than in non-infarct group (T=10.930, P=0.000). However, VMR value was significantly higher in patients with new-onset small-artery occlusion stroke than in non-infarction group (T=−2.538, P=0.013). Scatter plots showed that aortic atherosclerotic stroke occurred mainly in patients with severe internal carotid artery stenosis, and VMR value in cerebral artery significantly decreased.
ConclusionDecreased VMR value is an important prognostic factor for the occurrence of aortic atherosclerotic stroke, and can be used as a reference for preoperative hemodynamic evaluation in patients with internal carotid artery stenosis.
Abstract
To investigate the relationship between cerebral vasomotor reactivity (VMR) and acute stroke in patients with internal carotid artery stenosis.
Methods54 patients with internal carotid artery stenosis were enrolled. VMR was calculated by transcranial Doppler monitoring of the velocity of blood flow. 3-Dimensional dynamic contrast enhanced magnetic resonance angiography was used to detect stenosis, and diffusion weighted imaging was used to detect infarction.
ResultsVMR value was significantly lower in patients with carotid artery stenosis than in control group (T=3.112, P=0.002), and significantly lower in patients with aortic atherosclerotic stroke than in non-infarct group (T=10.930, P=0.000). However, VMR value was significantly higher in patients with new-onset small-artery occlusion stroke than in non-infarction group (T=−2.538, P=0.013). Scatter plots showed that aortic atherosclerotic stroke occurred mainly in patients with severe internal carotid artery stenosis, and VMR value in cerebral artery significantly decreased.
ConclusionDecreased VMR value is an important prognostic factor for the occurrence of aortic atherosclerotic stroke, and can be used as a reference for preoperative hemodynamic evaluation in patients with internal carotid artery stenosis.
Keywords
Vasomotor reactivity, Transcranial Doppler, Carotid artery stenosis, Cerebral infarction, Stroke
About this articleTitle
Cerebral vasomotor reactivity predicts the development of acute stroke in patients with internal carotid artery stenosis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
374-378
Published online
2018-01-08
Page views
310
Article views/downloads
656
DOI
10.1016/j.pjnns.2017.12.015
Bibliographic record
Neurol Neurochir Pol 2018;52(3):374-378.
Keywords
Vasomotor reactivity
Transcranial Doppler
Carotid artery stenosis
Cerebral infarction
Stroke
Authors
Keju Ju
Lingling Zhong
Xiaoyu Ni
Hua Cao
Guanliang Cheng
Lianshu Ding
