open access

Vol 52, No 3 (2018)
Review article
Submitted: 2018-01-11
Get Citation

Effectiveness of complex regional pain syndrome treatment: A systematic review

Andrzej Żyluk, Piotr Puchalski
DOI: 10.1016/j.pjnns.2018.03.001
·
Neurol Neurochir Pol 2018;52(3):326-333.

open access

Vol 52, No 3 (2018)
Review article
Submitted: 2018-01-11

Abstract

Complex regional pain syndrome (CRPS) is a descriptive term for a complex of symptoms and signs typically occurring following trauma of the extremity. Typical symptomatology includes severe pain, swelling, vasomotor instability and functional impairment of the affected limb. At present there is no one, effective method of treatment of the condition. A large number of treatments have been investigated but major multicentre randomized controlled trials are lacking. This study presents the results of a systematic review of the evidence on effectiveness of treatment methods in CRPS.

It is a follow-up to earlier reviews of randomized controlled trials on CRPS treatment published between 1966 and 2016. Results. The review of randomized controlled trials showed that only bisphosphonates were found to give uniformly positive effects, statistically significantly better than placebo. Improvement has been reported with topical dimethyl sulfoxide, systemic steroids, spinal cord stimulation and graded motor imagery/mirror therapy programmes. The available evidence does not support the use of other treatments in CRPS, however they are frequently used in clinical practice.

Conclusion

Available evidence, although numerous, does not necessarily reflect what is truly effective and what is sham in the management of CRPS.

Abstract

Complex regional pain syndrome (CRPS) is a descriptive term for a complex of symptoms and signs typically occurring following trauma of the extremity. Typical symptomatology includes severe pain, swelling, vasomotor instability and functional impairment of the affected limb. At present there is no one, effective method of treatment of the condition. A large number of treatments have been investigated but major multicentre randomized controlled trials are lacking. This study presents the results of a systematic review of the evidence on effectiveness of treatment methods in CRPS.

It is a follow-up to earlier reviews of randomized controlled trials on CRPS treatment published between 1966 and 2016. Results. The review of randomized controlled trials showed that only bisphosphonates were found to give uniformly positive effects, statistically significantly better than placebo. Improvement has been reported with topical dimethyl sulfoxide, systemic steroids, spinal cord stimulation and graded motor imagery/mirror therapy programmes. The available evidence does not support the use of other treatments in CRPS, however they are frequently used in clinical practice.

Conclusion

Available evidence, although numerous, does not necessarily reflect what is truly effective and what is sham in the management of CRPS.

Get Citation

Keywords

Complex regional pain syndrome – treatment, Systematic review, Randomized controlled trials

About this article
Title

Effectiveness of complex regional pain syndrome treatment: A systematic review

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 3 (2018)

Pages

326-333

DOI

10.1016/j.pjnns.2018.03.001

Bibliographic record

Neurol Neurochir Pol 2018;52(3):326-333.

Keywords

Complex regional pain syndrome – treatment
Systematic review
Randomized controlled trials

Authors

Andrzej Żyluk
Piotr Puchalski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl