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Life-threatening parkinsonism-hyperpyrexia syndrome following bilateral deep brain stimulation of the subthalamic nucleus
Affiliations- Department of Neurosurgery, Liv Hospital, Istanbul, Türkiye
- Department of Genetics, Institute of Aziz Sancar Experimental Medicine (ASDETAE), Istanbul University, Istanbul, Türkiye
- Turkey Spastic Children Foundation, Consultant Neurologist, Istanbul, Türkiye
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Abstract
Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times. Half of these cases resulted in fatalities. Herein, we report on an early diagnosed case of PHS following bilateral STN-DBS which was successfully treated with the administration of dopamine agonists, fluid replacement, and activation of DBS.
Abstract
Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times. Half of these cases resulted in fatalities. Herein, we report on an early diagnosed case of PHS following bilateral STN-DBS which was successfully treated with the administration of dopamine agonists, fluid replacement, and activation of DBS.
Keywords
Parkinson' s disease, Deep brain stimulation, Subthalamic nucleus, Parkinsonism-hyperpyrexia syndrome, Neuroleptic malignant syndrome
About this articleTitle
Life-threatening parkinsonism-hyperpyrexia syndrome following bilateral deep brain stimulation of the subthalamic nucleus
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
289-292
Published online
2017-12-06
Page views
398
Article views/downloads
450
DOI
10.1016/j.pjnns.2017.11.012
Bibliographic record
Neurol Neurochir Pol 2018;52(2):289-292.
Keywords
Parkinson's disease
Deep brain stimulation
Subthalamic nucleus
Parkinsonism-hyperpyrexia syndrome
Neuroleptic malignant syndrome
Authors
Mehmet Osman Akçakaya
Nihan Hande Akçakaya
Mustafa Ömür Kasımcan
Talat Kırış
