open access

Vol 52, No 2 (2018)
Case reports
Submitted: 2017-07-12
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Life-threatening parkinsonism-hyperpyrexia syndrome following bilateral deep brain stimulation of the subthalamic nucleus

Mehmet Osman Akçakaya, Nihan Hande Akçakaya, Mustafa Ömür Kasımcan, Talat Kırış
DOI: 10.1016/j.pjnns.2017.11.012
·
Neurol Neurochir Pol 2018;52(2):289-292.

open access

Vol 52, No 2 (2018)
Case reports
Submitted: 2017-07-12

Abstract

Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times. Half of these cases resulted in fatalities. Herein, we report on an early diagnosed case of PHS following bilateral STN-DBS which was successfully treated with the administration of dopamine agonists, fluid replacement, and activation of DBS.

Abstract

Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times. Half of these cases resulted in fatalities. Herein, we report on an early diagnosed case of PHS following bilateral STN-DBS which was successfully treated with the administration of dopamine agonists, fluid replacement, and activation of DBS.

Get Citation

Keywords

Parkinson' s disease, Deep brain stimulation, Subthalamic nucleus, Parkinsonism-hyperpyrexia syndrome, Neuroleptic malignant syndrome

About this article
Title

Life-threatening parkinsonism-hyperpyrexia syndrome following bilateral deep brain stimulation of the subthalamic nucleus

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 2 (2018)

Pages

289-292

DOI

10.1016/j.pjnns.2017.11.012

Bibliographic record

Neurol Neurochir Pol 2018;52(2):289-292.

Keywords

Parkinson's disease
Deep brain stimulation
Subthalamic nucleus
Parkinsonism-hyperpyrexia syndrome
Neuroleptic malignant syndrome

Authors

Mehmet Osman Akçakaya
Nihan Hande Akçakaya
Mustafa Ömür Kasımcan
Talat Kırış

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