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Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume
Affiliations- University Clinic for Neurosurgery, Medical Faculty, “Ss. Cyril and Methodius” University, Skopje, North Macedonia
- Faculty of Natural Sciences and Mathematics, “Ss. Cyril and Methodius” University, Skopje, North Macedonia
- Faculty of Medicine, University of Niš, Niš
- Center of Radiology, Clinical Center Niš, Niš
- University Clinic for Neurology, Medical Faculty, “Ss. Cyril and Methodius” University, Skopje, North Macedonia
- University Clinic for Radiology, Belgradska bb, Skopje, North Macedonia
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Abstract
We aimed to evaluate the prognostic values, contribution and interactions of the peripheral blood plasma glutamate and tumor-necrosis factor-α (TNF-α) levels toward the formation of the perifocal edema in patients with intracerebral hemorrhage (ICH).
MethodsFifty patients with ICH and fifty healthy controls were included in the study. The peripheral markers were detected by high-sensitivity ELISA.
ResultsA highly significant differences in plasma glutamate and TNF-α levels with good separation of their values was detected between patients and healthy controls. The two variables correlated with the severity of the symptoms and the initial volume of the ICH at admission. Both peripheral glutamate and TNF-α levels at admission were estimated as significant predictors for the formation of the perifocal edema five days after ICH; nevertheless, it was shown that they independently contribute to the development of the edema, without effects of interaction and regardless the localization of the ICH.
ConclusionsOur results support the idea for the significance of glutamate and TNF-α as peripheral markers for excitotoxicity and inflammation in ICH patients. The developed multiple regression model for prediction of the development of the edema could be beneficial in decision making between conservative treatment and surgical intervention in the clinical practice.
Abstract
We aimed to evaluate the prognostic values, contribution and interactions of the peripheral blood plasma glutamate and tumor-necrosis factor-α (TNF-α) levels toward the formation of the perifocal edema in patients with intracerebral hemorrhage (ICH).
MethodsFifty patients with ICH and fifty healthy controls were included in the study. The peripheral markers were detected by high-sensitivity ELISA.
ResultsA highly significant differences in plasma glutamate and TNF-α levels with good separation of their values was detected between patients and healthy controls. The two variables correlated with the severity of the symptoms and the initial volume of the ICH at admission. Both peripheral glutamate and TNF-α levels at admission were estimated as significant predictors for the formation of the perifocal edema five days after ICH; nevertheless, it was shown that they independently contribute to the development of the edema, without effects of interaction and regardless the localization of the ICH.
ConclusionsOur results support the idea for the significance of glutamate and TNF-α as peripheral markers for excitotoxicity and inflammation in ICH patients. The developed multiple regression model for prediction of the development of the edema could be beneficial in decision making between conservative treatment and surgical intervention in the clinical practice.
Keywords
Intracerebral hemorrhage, Tumor necrosis factor α, Glutamate, Excitotoxicity, Perifocal edema
About this articleTitle
Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
207-214
Published online
2017-10-19
Page views
261
Article views/downloads
339
DOI
10.1016/j.pjnns.2017.10.003
Bibliographic record
Neurol Neurochir Pol 2018;52(2):207-214.
Keywords
Intracerebral hemorrhage
Tumor necrosis factor α
Glutamate
Excitotoxicity
Perifocal edema
Authors
Vladimir Rendevski
Boris Aleksovski
Dragan Stojanov
Vasko Aleksovski
Ana Mihajlovska Rendevska
Milena Kolevska
Kiro Stojanoski
Icko Gjorgoski
