open access

Vol 52, No 2 (2018)
Original research articles
Submitted: 2017-07-31
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Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume

Vladimir Rendevski, Boris Aleksovski, Dragan Stojanov, Vasko Aleksovski, Ana Mihajlovska Rendevska, Milena Kolevska, Kiro Stojanoski, Icko Gjorgoski
DOI: 10.1016/j.pjnns.2017.10.003
·
Neurol Neurochir Pol 2018;52(2):207-214.

open access

Vol 52, No 2 (2018)
Original research articles
Submitted: 2017-07-31

Abstract

Objective

We aimed to evaluate the prognostic values, contribution and interactions of the peripheral blood plasma glutamate and tumor-necrosis factor-α (TNF-α) levels toward the formation of the perifocal edema in patients with intracerebral hemorrhage (ICH).

Methods

Fifty patients with ICH and fifty healthy controls were included in the study. The peripheral markers were detected by high-sensitivity ELISA.

Results

A highly significant differences in plasma glutamate and TNF-α levels with good separation of their values was detected between patients and healthy controls. The two variables correlated with the severity of the symptoms and the initial volume of the ICH at admission. Both peripheral glutamate and TNF-α levels at admission were estimated as significant predictors for the formation of the perifocal edema five days after ICH; nevertheless, it was shown that they independently contribute to the development of the edema, without effects of interaction and regardless the localization of the ICH.

Conclusions

Our results support the idea for the significance of glutamate and TNF-α as peripheral markers for excitotoxicity and inflammation in ICH patients. The developed multiple regression model for prediction of the development of the edema could be beneficial in decision making between conservative treatment and surgical intervention in the clinical practice.

Abstract

Objective

We aimed to evaluate the prognostic values, contribution and interactions of the peripheral blood plasma glutamate and tumor-necrosis factor-α (TNF-α) levels toward the formation of the perifocal edema in patients with intracerebral hemorrhage (ICH).

Methods

Fifty patients with ICH and fifty healthy controls were included in the study. The peripheral markers were detected by high-sensitivity ELISA.

Results

A highly significant differences in plasma glutamate and TNF-α levels with good separation of their values was detected between patients and healthy controls. The two variables correlated with the severity of the symptoms and the initial volume of the ICH at admission. Both peripheral glutamate and TNF-α levels at admission were estimated as significant predictors for the formation of the perifocal edema five days after ICH; nevertheless, it was shown that they independently contribute to the development of the edema, without effects of interaction and regardless the localization of the ICH.

Conclusions

Our results support the idea for the significance of glutamate and TNF-α as peripheral markers for excitotoxicity and inflammation in ICH patients. The developed multiple regression model for prediction of the development of the edema could be beneficial in decision making between conservative treatment and surgical intervention in the clinical practice.

Get Citation

Keywords

Intracerebral hemorrhage, Tumor necrosis factor α, Glutamate, Excitotoxicity, Perifocal edema

About this article
Title

Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 2 (2018)

Pages

207-214

DOI

10.1016/j.pjnns.2017.10.003

Bibliographic record

Neurol Neurochir Pol 2018;52(2):207-214.

Keywords

Intracerebral hemorrhage
Tumor necrosis factor α
Glutamate
Excitotoxicity
Perifocal edema

Authors

Vladimir Rendevski
Boris Aleksovski
Dragan Stojanov
Vasko Aleksovski
Ana Mihajlovska Rendevska
Milena Kolevska
Kiro Stojanoski
Icko Gjorgoski

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