open access

Vol 52, No 1 (2018)
Case reports
Submitted: 2017-07-03
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Substantial disease exacerbation in a patient with relapsing-remitting multiple sclerosis after withdrawal from siponimod

Tomasz Litwin, Łukasz Smoliński, Anna Członkowka
DOI: 10.1016/j.pjnns.2017.10.001
·
Neurol Neurochir Pol 2018;52(1):98-101.

open access

Vol 52, No 1 (2018)
Case reports
Submitted: 2017-07-03

Abstract

Among patients with multiple sclerosis, discontinuing highly effective disease-modifying treatments can potentially lead to severe disease recurrence, especially cessation of natalizumab and fingolimod. Similar to fingolimod, siponimod is a sphingosine-1-phosphate receptor modulator that inhibits the egress of a lymphocyte subpopulation from lymph nodes. In the present case report, we describe a patient with MS who experienced substantial disease exacerbation after withdrawal from siponimod.

Abstract

Among patients with multiple sclerosis, discontinuing highly effective disease-modifying treatments can potentially lead to severe disease recurrence, especially cessation of natalizumab and fingolimod. Similar to fingolimod, siponimod is a sphingosine-1-phosphate receptor modulator that inhibits the egress of a lymphocyte subpopulation from lymph nodes. In the present case report, we describe a patient with MS who experienced substantial disease exacerbation after withdrawal from siponimod.

Get Citation

Keywords

Multiple sclerosis, Siponimod, Withdrawal, Rebound, Fingolimod

About this article
Title

Substantial disease exacerbation in a patient with relapsing-remitting multiple sclerosis after withdrawal from siponimod

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 1 (2018)

Pages

98-101

DOI

10.1016/j.pjnns.2017.10.001

Bibliographic record

Neurol Neurochir Pol 2018;52(1):98-101.

Keywords

Multiple sclerosis
Siponimod
Withdrawal
Rebound
Fingolimod

Authors

Tomasz Litwin
Łukasz Smoliński
Anna Członkowka

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