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Treatment of acute basilar artery occlusion: Systematic review and meta-analysis
- Department of Adult Neurology, Medical University of Gdansk and University Clinical Centre in Gdansk, ul. Dębinki 7, Gdańsk, Poland
open access
Abstract
Acute basilar artery occlusion (BAO) results in strokes characterized by poor outcome. Intravenous and intraarterial thrombolysis with rt-PA (IV rt-PA and IA rt-PA, respectively) and mechanical thrombectomy (MT) are the most commonly used techniques to treat BAO, but their efficacy remains unclear. Unlike in previous papers, we compared all three methods of the treatment in a single work, including an update of meta-analysis regarding each of the three therapeutic approaches with recent trials.
MethodsWe systematically reviewed all original studies testing the efficacy of any of the three basic methods of BAO treatment dated up to the end of Jan 2017.
ResultsThe final analysis included 31 studies that summarized 1358 patients. These subjects were organized into three therapeutic groups: IV rt-PA, IA rt-PA±IV rt-PA, MT±IV rt-PA±IA rt-PA. The weighted pooled estimates of a favorable outcome (mRS 0–2) were 32.57% (95% CI 16.44–51.03%/I2=67.5%, p=0.0795) in the first group, 22.56% (95% CI 16.85–28.79%/I2=52.1%, p=0.027) in the second group, and 37.04% (95% CI 32.27–41.92%/I2=32%, p=0.0895) in the third group. The Q-test subgroup analysis revealed the statistical superiority of MT±IV rt-PA±IA rt-PA over IA rt-PA±IV rt-PA (mRS 0–2: p=0.0003, mRS 6: p=0.0010) and over any rt-PA administration (either IV rt-PA or IA rt-PA±IV rt-PA) (mRS 0–2: p=0.0006, mRS 6: p=0.0056).
ConclusionsCurrent data on the effects of the three basic approaches of the treatment of BAO are insufficient to generate high-class EBM guidelines. MT seems to be the most effective method of the treatment of acute BAO. The efficacy of IV or IA thrombolytic therapy in this indication remains unclear.
Abstract
Acute basilar artery occlusion (BAO) results in strokes characterized by poor outcome. Intravenous and intraarterial thrombolysis with rt-PA (IV rt-PA and IA rt-PA, respectively) and mechanical thrombectomy (MT) are the most commonly used techniques to treat BAO, but their efficacy remains unclear. Unlike in previous papers, we compared all three methods of the treatment in a single work, including an update of meta-analysis regarding each of the three therapeutic approaches with recent trials.
MethodsWe systematically reviewed all original studies testing the efficacy of any of the three basic methods of BAO treatment dated up to the end of Jan 2017.
ResultsThe final analysis included 31 studies that summarized 1358 patients. These subjects were organized into three therapeutic groups: IV rt-PA, IA rt-PA±IV rt-PA, MT±IV rt-PA±IA rt-PA. The weighted pooled estimates of a favorable outcome (mRS 0–2) were 32.57% (95% CI 16.44–51.03%/I2=67.5%, p=0.0795) in the first group, 22.56% (95% CI 16.85–28.79%/I2=52.1%, p=0.027) in the second group, and 37.04% (95% CI 32.27–41.92%/I2=32%, p=0.0895) in the third group. The Q-test subgroup analysis revealed the statistical superiority of MT±IV rt-PA±IA rt-PA over IA rt-PA±IV rt-PA (mRS 0–2: p=0.0003, mRS 6: p=0.0010) and over any rt-PA administration (either IV rt-PA or IA rt-PA±IV rt-PA) (mRS 0–2: p=0.0006, mRS 6: p=0.0056).
ConclusionsCurrent data on the effects of the three basic approaches of the treatment of BAO are insufficient to generate high-class EBM guidelines. MT seems to be the most effective method of the treatment of acute BAO. The efficacy of IV or IA thrombolytic therapy in this indication remains unclear.
Keywords
Ischemic stroke, Basilar artery occlusion, Thrombolysis, Thrombectomy, Embolectomy
Title
Treatment of acute basilar artery occlusion: Systematic review and meta-analysis
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
486-496
Page views
519
Article views/downloads
1126
DOI
10.1016/j.pjnns.2017.07.012
Bibliographic record
Neurol Neurochir Pol 2017;51(6):486-496.
Keywords
Ischemic stroke
Basilar artery occlusion
Thrombolysis
Thrombectomy
Embolectomy
Authors
Adam Wyszomirski
Sebastian Szczyrba
Dominika Tomaka
Bartosz Karaszewski