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Reorganization of language centers in patients with brain tumors located in eloquent speech areas – A pre- and postoperative preliminary fMRI study
- Department of Radiological and Isotopic Diagnosis and Therapy, Medical University of Lodz, Central Clinical Hospital, Czechoslowacka 8/10, Lodz, Poland
- Department of Neurosurgery, Medical University of Łódź, Kopcińskiego 22, Łódź, Poland
- Institute of Health Sciences, University of Social Sciences, Gdańska 121, Łódź, Poland
- Department of Radiology and Diagnostic Imaging, Medical University of Łódź, Kopcińskiego 22, Łódź, Poland
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Abstract
The aim of this study was to determine in pre- and postsurgical fMRI studies the rearrangement of the Broca's and Wernicke's areas and the lateralization index for these areas in patients with brain tumors located near speech centers. Impact of the surgical treatment on the brain plasticity was evaluated.
Materials and methodsPre- and postoperative fMRI examinations were performed in 10 patients with low grade glial, left-sided brain tumors located close to the Broca's (5 patients) or Wernicke's area (5 patients). BOLD signal was recorded in regions of interest: Broca's and Wernicke's areas, and their anatomic right-sided homologues.
ResultsIn the preoperative fMRI study the left Broca's area was activated in all cases. The right Broca's area was activated in all the patients with no speech disorders. In the postoperative fMRI the activation of both Broca's areas increased in two cases. In other two cases activation of one of the Broca's area increased along with the decrease in the contralateral hemisphere.
In all patients with temporal lobe tumors, the right Wernicke's area was activated in the pre- and postsurgical fMRI. After the operation, in two patients with speech disorder, the activation of both Broca's areas decreased and the activation of one of the Wernicke's areas increased.
ConclusionsIn the cases of tumors localized near the left Broca's area, a transfer of the function to the healthy hemisphere seems to take place. Resection of tumors located near Broca's or Wernicke's areas may lead to relocation of the brain language centers.
Abstract
The aim of this study was to determine in pre- and postsurgical fMRI studies the rearrangement of the Broca's and Wernicke's areas and the lateralization index for these areas in patients with brain tumors located near speech centers. Impact of the surgical treatment on the brain plasticity was evaluated.
Materials and methodsPre- and postoperative fMRI examinations were performed in 10 patients with low grade glial, left-sided brain tumors located close to the Broca's (5 patients) or Wernicke's area (5 patients). BOLD signal was recorded in regions of interest: Broca's and Wernicke's areas, and their anatomic right-sided homologues.
ResultsIn the preoperative fMRI study the left Broca's area was activated in all cases. The right Broca's area was activated in all the patients with no speech disorders. In the postoperative fMRI the activation of both Broca's areas increased in two cases. In other two cases activation of one of the Broca's area increased along with the decrease in the contralateral hemisphere.
In all patients with temporal lobe tumors, the right Wernicke's area was activated in the pre- and postsurgical fMRI. After the operation, in two patients with speech disorder, the activation of both Broca's areas decreased and the activation of one of the Wernicke's areas increased.
ConclusionsIn the cases of tumors localized near the left Broca's area, a transfer of the function to the healthy hemisphere seems to take place. Resection of tumors located near Broca's or Wernicke's areas may lead to relocation of the brain language centers.
Keywords
Language, Functional magnetic resonance imaging, Brain mapping
Title
Reorganization of language centers in patients with brain tumors located in eloquent speech areas – A pre- and postoperative preliminary fMRI study
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
403-410
Page views
277
Article views/downloads
490
DOI
10.1016/j.pjnns.2017.07.010
Bibliographic record
Neurol Neurochir Pol 2017;51(5):403-410.
Keywords
Language
Functional magnetic resonance imaging
Brain mapping
Authors
Katarzyna Gębska-Kośla
Bartosz Bryszewski
Dariusz J. Jaskólski
Jan Fortuniak
Maciej Niewodniczy
Ludomir Stefańczyk
Agata Majos