open access

Vol 51, No 5 (2017)
Original research articles
Submitted: 2017-01-01
Get Citation

Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease

Małgorzata Dec-Ćwiek, Marcin Tutaj, Jean-Michel Gracies, Jens Volkmann, Monika Rudzińska, Agnieszka Słowik, Andrzej Szczudlik
DOI: 10.1016/j.pjnns.2017.06.002
·
Neurol Neurochir Pol 2017;51(5):354-360.

open access

Vol 51, No 5 (2017)
Original research articles
Submitted: 2017-01-01

Abstract

Objective

To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).

Methods

Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their “med-off” (OFF) and “med-on” (ON) status, whereas 20 DBS-STN treated patients were assessed in their “med-off, stim-off” (OFF) and “med-off, stim-on” (ON) status.

Results

In all PD patients the saccades in the OFF status were delayed, slower and smaller (p<0.01) than in controls. In pharmacologically treated patients all studied parameters showed tendency to worsen in the ON status as compared to the OFF status. In contrast, activating DBS-STN showed tendency to improve all studied parameters. Comparison of the studied saccade parameters between the ON status of DBS-STN treated patients, ON status of the pharmacologically treated patients and the controls showed that 73% of these parameters in the DBS-STN treated patients were similar as in the controls. While in the pharmacologically treated patients only 26% of these parameters were similar as in the controls.

Conclusion

This prospective study comparing the influence of l-dopa and DBS-STN on saccades in advanced PD showed contrasting results between these two treatments; the majority of the studied parameters in patients on DBS-STN were similar as in the controls.

Abstract

Objective

To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).

Methods

Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their “med-off” (OFF) and “med-on” (ON) status, whereas 20 DBS-STN treated patients were assessed in their “med-off, stim-off” (OFF) and “med-off, stim-on” (ON) status.

Results

In all PD patients the saccades in the OFF status were delayed, slower and smaller (p<0.01) than in controls. In pharmacologically treated patients all studied parameters showed tendency to worsen in the ON status as compared to the OFF status. In contrast, activating DBS-STN showed tendency to improve all studied parameters. Comparison of the studied saccade parameters between the ON status of DBS-STN treated patients, ON status of the pharmacologically treated patients and the controls showed that 73% of these parameters in the DBS-STN treated patients were similar as in the controls. While in the pharmacologically treated patients only 26% of these parameters were similar as in the controls.

Conclusion

This prospective study comparing the influence of l-dopa and DBS-STN on saccades in advanced PD showed contrasting results between these two treatments; the majority of the studied parameters in patients on DBS-STN were similar as in the controls.

Get Citation

Keywords

Saccade, Deep brain stimulation, Subthalamic nucleus, Levodopa, Parkinson' s disease

About this article
Title

Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 51, No 5 (2017)

Pages

354-360

DOI

10.1016/j.pjnns.2017.06.002

Bibliographic record

Neurol Neurochir Pol 2017;51(5):354-360.

Keywords

Saccade
Deep brain stimulation
Subthalamic nucleus
Levodopa
Parkinson's disease

Authors

Małgorzata Dec-Ćwiek
Marcin Tutaj
Jean-Michel Gracies
Jens Volkmann
Monika Rudzińska
Agnieszka Słowik
Andrzej Szczudlik

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl