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Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease
Affiliations- Department of Neurology, Jagiellonian University, Medical College, Kraków, Poland
- Department of Neurorehabilitation, EA BIOTN, Henri Mondor Hospital, Créteil, France
- Department of Neurology, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Department of Neurology, Medical University of Silesia, Faculty of Medicine, Katowice, Poland
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Abstract
To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).
MethodsVisually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their “med-off” (OFF) and “med-on” (ON) status, whereas 20 DBS-STN treated patients were assessed in their “med-off, stim-off” (OFF) and “med-off, stim-on” (ON) status.
ResultsIn all PD patients the saccades in the OFF status were delayed, slower and smaller (p<0.01) than in controls. In pharmacologically treated patients all studied parameters showed tendency to worsen in the ON status as compared to the OFF status. In contrast, activating DBS-STN showed tendency to improve all studied parameters. Comparison of the studied saccade parameters between the ON status of DBS-STN treated patients, ON status of the pharmacologically treated patients and the controls showed that 73% of these parameters in the DBS-STN treated patients were similar as in the controls. While in the pharmacologically treated patients only 26% of these parameters were similar as in the controls.
ConclusionThis prospective study comparing the influence of l-dopa and DBS-STN on saccades in advanced PD showed contrasting results between these two treatments; the majority of the studied parameters in patients on DBS-STN were similar as in the controls.
Abstract
To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).
MethodsVisually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their “med-off” (OFF) and “med-on” (ON) status, whereas 20 DBS-STN treated patients were assessed in their “med-off, stim-off” (OFF) and “med-off, stim-on” (ON) status.
ResultsIn all PD patients the saccades in the OFF status were delayed, slower and smaller (p<0.01) than in controls. In pharmacologically treated patients all studied parameters showed tendency to worsen in the ON status as compared to the OFF status. In contrast, activating DBS-STN showed tendency to improve all studied parameters. Comparison of the studied saccade parameters between the ON status of DBS-STN treated patients, ON status of the pharmacologically treated patients and the controls showed that 73% of these parameters in the DBS-STN treated patients were similar as in the controls. While in the pharmacologically treated patients only 26% of these parameters were similar as in the controls.
ConclusionThis prospective study comparing the influence of l-dopa and DBS-STN on saccades in advanced PD showed contrasting results between these two treatments; the majority of the studied parameters in patients on DBS-STN were similar as in the controls.
Keywords
Saccade, Deep brain stimulation, Subthalamic nucleus, Levodopa, Parkinson' s disease
About this articleTitle
Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
354-360
Page views
375
Article views/downloads
565
DOI
10.1016/j.pjnns.2017.06.002
Bibliographic record
Neurol Neurochir Pol 2017;51(5):354-360.
Keywords
Saccade
Deep brain stimulation
Subthalamic nucleus
Levodopa
Parkinson's disease
Authors
Małgorzata Dec-Ćwiek
Marcin Tutaj
Jean-Michel Gracies
Jens Volkmann
Monika Rudzińska
Agnieszka Słowik
Andrzej Szczudlik
