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Brain-derived neurotrophic factor levels under chronic natalizumab treatment in multiple sclerosis. A preliminary report
Affiliations- Department of Neurosciences, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania
- Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania
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Abstract
Our main purpose was to investigate if the chronic treatment with the disease-modifying drug natalizumab shows quantifiable effect on BDNF levels in multiple sclerosis patients.
Materials and MethodsBDNF plasma concentration was evaluated using enzyme-linked immunosorbent assay in healthy individuals, not treated multiple sclerosis patients and patients treated with natalizumab.
ResultsMultiple sclerosis patients have a significantly lower amount of peripheral BDNF than healthy individuals. Patients treated with natalizumab have significantly higher BDNF levels than not treated patients.
ConclusionsChronic natalizumab treatment is associated with significantly increased plasma BDNF concentration in multiple sclerosis.
Abstract
Our main purpose was to investigate if the chronic treatment with the disease-modifying drug natalizumab shows quantifiable effect on BDNF levels in multiple sclerosis patients.
Materials and MethodsBDNF plasma concentration was evaluated using enzyme-linked immunosorbent assay in healthy individuals, not treated multiple sclerosis patients and patients treated with natalizumab.
ResultsMultiple sclerosis patients have a significantly lower amount of peripheral BDNF than healthy individuals. Patients treated with natalizumab have significantly higher BDNF levels than not treated patients.
ConclusionsChronic natalizumab treatment is associated with significantly increased plasma BDNF concentration in multiple sclerosis.
Keywords
BDNF, MS, Natalizumab
About this articleTitle
Brain-derived neurotrophic factor levels under chronic natalizumab treatment in multiple sclerosis. A preliminary report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
221-226
Page views
267
Article views/downloads
553
DOI
10.1016/j.pjnns.2017.03.002
Bibliographic record
Neurol Neurochir Pol 2017;51(3):221-226.
Keywords
BDNF
MS
Natalizumab
Authors
Vitalie Văcăraş
Zoltán Zsigmond Major
Anca Dana Buzoianu
