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The Heidenhain variant of Creutzfeldt–Jakob disease and concomitant tau pathology: A case report
Affiliations- Department of Neurology, Regional Hospital Pardubice, Czech Republic
- Faculty of Health Studies, University of Pardubice, Pardubice, Czech Republic
- Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and the General University Hospital, Prague, Czech Republic
- Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic
- Department of Pathology, First Faculty of Medicine, Charles University in Prague and the General University Hospital, Prague, Czech Republic
- Department of Neurology, Thomayer Hospital, Prague, Czech Republic
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Abstract
•The Heidenhain form of CJD is a rare variant with predominantly visual symptoms.•Clinical findings correlate with involvement of posterior cortical regions.•MRI found typical cortical hyperintensities in the occipital regions.•Neuropathology revealed histopathological changes consistent with prion disease.•Hyperphosphorylated tau deposits were an additional and interesting finding in our case.
Abstract
•The Heidenhain form of CJD is a rare variant with predominantly visual symptoms.•Clinical findings correlate with involvement of posterior cortical regions.•MRI found typical cortical hyperintensities in the occipital regions.•Neuropathology revealed histopathological changes consistent with prion disease.•Hyperphosphorylated tau deposits were an additional and interesting finding in our case.
Keywords
Prion, Creutzfeldt–Jakob disease, Visuospatial dysfunction, Heidenhain variant
About this articleTitle
The Heidenhain variant of Creutzfeldt–Jakob disease and concomitant tau pathology: A case report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
197-200
Page views
268
Article views/downloads
541
DOI
10.1016/j.pjnns.2017.01.011
Bibliographic record
Neurol Neurochir Pol 2017;51(2):197-200.
Keywords
Prion
Creutzfeldt–Jakob disease
Visuospatial dysfunction
Heidenhain variant
Authors
Edvard Ehler
Michael Pipka
Alena Meleková
Petra Mandysová
Silvie Johanidesová
Radoslav Matěj
Robert Rusina
