open access

Vol 51, No 2 (2017)
Short communications
Submitted: 2016-01-07
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Age dependence of critical pressure in the segments and branches of the circle of Willis

Adam Piechna, Leszek Lombarski, Paweł Krajewski, Bogdan Ciszek, Krzysztof Cieslicki
DOI: 10.1016/j.pjnns.2017.01.003
·
Neurol Neurochir Pol 2017;51(2):146-148.

open access

Vol 51, No 2 (2017)
Short communications
Submitted: 2016-01-07

Abstract

Spontaneous intracranial haemorrhage is one of the most dramatic neurological disasters. The source of haemorrhage is linked to the pathology of the arterial wall or is unknown. Because the risk of haemorrhagic stroke increases with age, we tried to investigate the relationship between age and rupture pressure of cerebral arteries. In the presented study, 51 segments of large cerebral arteries (at the level of the circle of Willis and its incoming and outgoing branches) were obtained from 33 cadaver brains aged 12–86 years. The segments were pressurized up to the rupture. The rupture pressure was noted. The highest observed pressure was 4.3atm in specimen aged 24 years. The lowest pressure 1.19atm was observed in specimen aged 80 years. The mean value of rupture pressure of all investigated segments was 2.28atm.

Statistical analysis showed a nonlinear exponential decrease of the rupture pressure of the large cerebral arteries with age. The main conclusion from our study is that drop of cerebral arteries strength is observed to the age of 40. Later this lowering is visible but not so evident.

Abstract

Spontaneous intracranial haemorrhage is one of the most dramatic neurological disasters. The source of haemorrhage is linked to the pathology of the arterial wall or is unknown. Because the risk of haemorrhagic stroke increases with age, we tried to investigate the relationship between age and rupture pressure of cerebral arteries. In the presented study, 51 segments of large cerebral arteries (at the level of the circle of Willis and its incoming and outgoing branches) were obtained from 33 cadaver brains aged 12–86 years. The segments were pressurized up to the rupture. The rupture pressure was noted. The highest observed pressure was 4.3atm in specimen aged 24 years. The lowest pressure 1.19atm was observed in specimen aged 80 years. The mean value of rupture pressure of all investigated segments was 2.28atm.

Statistical analysis showed a nonlinear exponential decrease of the rupture pressure of the large cerebral arteries with age. The main conclusion from our study is that drop of cerebral arteries strength is observed to the age of 40. Later this lowering is visible but not so evident.

Get Citation

Keywords

Arterial pressure, Cerebral artery, Cerebrovascular circulation, Intracranial haemorrhage, Rupture pressure

About this article
Title

Age dependence of critical pressure in the segments and branches of the circle of Willis

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 51, No 2 (2017)

Pages

146-148

DOI

10.1016/j.pjnns.2017.01.003

Bibliographic record

Neurol Neurochir Pol 2017;51(2):146-148.

Keywords

Arterial pressure
Cerebral artery
Cerebrovascular circulation
Intracranial haemorrhage
Rupture pressure

Authors

Adam Piechna
Leszek Lombarski
Paweł Krajewski
Bogdan Ciszek
Krzysztof Cieslicki

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