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Cognitive impairment and BDNF serum levels
Affiliations- Department of Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
- Department of Neurology, Central University Hospital, Katowice, Poland
- Department of Biostatistics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland
- Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
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Abstract
To investigate the alterations of brain-derived neurotrophic factor (BNDF) serum levels in subjects with different intensity of cognitive impairment and different neurodegenerative processes.
Material and methodsSerum BDNF levels were analyzed by ELISA kit in 378 subjects: 134 Alzheimer's disease (AD) patients, 115 amnestic mild cognitive impairment (MCI) patients, and 129 controls divided into two groups: neurodegenerative control group (ND), consisting of 49 Parkinson's disease patients without any cognitive complaints, and cognitively normal control group (CN), consisting of 80 subjects without any neurological disorders.
ResultsAD patients had significantly lower (p<0.001) BDNF serum levels compared to MCI, CN and ND controls. Age and education had significant influence on BDNF serum levels regardless the diagnosis or group assignment. We have found no influence of depression on BDNF serum levels either in our group as a whole, or in each group assessed separately. We found significant correlation between BDNF serum levels and cognitive impairments. After multiple comparisons between the groups, we found that, after adjustment for confounding factors (age, gender, education, depression, cognitive impairment), BDNF serum levels were the lowest in AD group (p=0.05).
ConclusionsAdvanced age and low educational level are associated with decreased BDNF serum levels. Decreased BDNF serum levels correspond to the severity of cognitive impairment. There is no correlation between BDNF serum levels and depressive symptoms.
Abstract
To investigate the alterations of brain-derived neurotrophic factor (BNDF) serum levels in subjects with different intensity of cognitive impairment and different neurodegenerative processes.
Material and methodsSerum BDNF levels were analyzed by ELISA kit in 378 subjects: 134 Alzheimer's disease (AD) patients, 115 amnestic mild cognitive impairment (MCI) patients, and 129 controls divided into two groups: neurodegenerative control group (ND), consisting of 49 Parkinson's disease patients without any cognitive complaints, and cognitively normal control group (CN), consisting of 80 subjects without any neurological disorders.
ResultsAD patients had significantly lower (p<0.001) BDNF serum levels compared to MCI, CN and ND controls. Age and education had significant influence on BDNF serum levels regardless the diagnosis or group assignment. We have found no influence of depression on BDNF serum levels either in our group as a whole, or in each group assessed separately. We found significant correlation between BDNF serum levels and cognitive impairments. After multiple comparisons between the groups, we found that, after adjustment for confounding factors (age, gender, education, depression, cognitive impairment), BDNF serum levels were the lowest in AD group (p=0.05).
ConclusionsAdvanced age and low educational level are associated with decreased BDNF serum levels. Decreased BDNF serum levels correspond to the severity of cognitive impairment. There is no correlation between BDNF serum levels and depressive symptoms.
Keywords
Brain-derived neurotrophic factor, Serum brain-derived neurotrophic factor level, Cognitive impairment, Dementia, Alzheimer' s disease
About this articleTitle
Cognitive impairment and BDNF serum levels
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
24-32
Page views
1374
Article views/downloads
1073
DOI
10.1016/j.pjnns.2016.10.001
Bibliographic record
Neurol Neurochir Pol 2017;51(1):24-32.
Keywords
Brain-derived neurotrophic factor
Serum brain-derived neurotrophic factor level
Cognitive impairment
Dementia
Alzheimer's disease
Authors
Joanna Siuda
Maja Patalong-Ogiewa
Weronika Żmuda
Magdalena Targosz-Gajniak
Ewa Niewiadomska
Iwona Matuszek
Halina Jędrzejowska-Szypułka
Monika Rudzińska-Bar
