open access

Vol 50, No 6 (2016)
Case reports
Submitted: 2015-11-08
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Hypophyseal metastases: A report of three cases and literature review

Janez Ravnik, Tomaz Smigoc, Gorazd Bunc, Bostjan Lanisnik, Ursa Ksela, Maja Ravnik, Tomaz Velnar
DOI: 10.1016/j.pjnns.2016.08.007
·
Neurol Neurochir Pol 2016;50(6):511-516.

open access

Vol 50, No 6 (2016)
Case reports
Submitted: 2015-11-08

Abstract

Metastatic tumours to the pituitary gland are rare. The most frequent are metastases from breast and lung. We describe three patients with metastatic tumours: (I) a 54-year-old patient with metastatic renal clear-cell carcinoma and consequent disturbances in visual acuity, cranial nerve paresis and panhypopituitarism, (II) a 60-year-old patient with a diffuse large B-cell lymphoma with panhypopituitarism and diabetes insipidus and (III) a 57-year-old patient with metastasis of breast cancer and panhypopituitarism, visual impairment and cranial nerve paresis. A transnasal endoscopic biopsy and resection of the tumour was performed in all patients, followed by the oncological treatment. Despite the rarity of the disease, it is important to suspect a metastatic pituitary tumour especially in the case of diabetes insipidus, ophthalmoplegia, rapid course of the disease and headaches. In 20–30% of patients, a metastasis to the pituitary is the first manifestation of a tumour of unknown origin. Surgical and adjuvant therapy may improve the quality of life. The survival is not affected, however, and the prognosis of the disease is usually poor.

Abstract

Metastatic tumours to the pituitary gland are rare. The most frequent are metastases from breast and lung. We describe three patients with metastatic tumours: (I) a 54-year-old patient with metastatic renal clear-cell carcinoma and consequent disturbances in visual acuity, cranial nerve paresis and panhypopituitarism, (II) a 60-year-old patient with a diffuse large B-cell lymphoma with panhypopituitarism and diabetes insipidus and (III) a 57-year-old patient with metastasis of breast cancer and panhypopituitarism, visual impairment and cranial nerve paresis. A transnasal endoscopic biopsy and resection of the tumour was performed in all patients, followed by the oncological treatment. Despite the rarity of the disease, it is important to suspect a metastatic pituitary tumour especially in the case of diabetes insipidus, ophthalmoplegia, rapid course of the disease and headaches. In 20–30% of patients, a metastasis to the pituitary is the first manifestation of a tumour of unknown origin. Surgical and adjuvant therapy may improve the quality of life. The survival is not affected, however, and the prognosis of the disease is usually poor.

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Keywords

Pituitary tumour, Metastases, Renal cell carcinoma, Lymphoma, Breast cancer

About this article
Title

Hypophyseal metastases: A report of three cases and literature review

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 6 (2016)

Pages

511-516

DOI

10.1016/j.pjnns.2016.08.007

Bibliographic record

Neurol Neurochir Pol 2016;50(6):511-516.

Keywords

Pituitary tumour
Metastases
Renal cell carcinoma
Lymphoma
Breast cancer

Authors

Janez Ravnik
Tomaz Smigoc
Gorazd Bunc
Bostjan Lanisnik
Ursa Ksela
Maja Ravnik
Tomaz Velnar

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