open access

Vol 50, No 6 (2016)
Review article
Submitted: 2015-10-17
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Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment

Olga Kuzawińska, Krzysztof Lis, Grzegorz Cessak, Dagmara Mirowska-Guzel, Ewa Bałkowiec-Iskra
DOI: 10.1016/j.pjnns.2016.07.012
·
Neurol Neurochir Pol 2016;50(6):463-467.

open access

Vol 50, No 6 (2016)
Review article
Submitted: 2015-10-17

Abstract

Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. Calcitonin gene-related peptide (CGRP) is an endogenous substance, which is regarded a key mediator released from trigeminovascular system after stimulation of sensory nerve endings, responsible for dilatation of peripheral vessels and sensory transmission. CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research. In the article we focus on the role of CGRP in the pathophysiology of migraine and present current data on CGRP antagonists and CGRP monoclonal antibodies.

Abstract

Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. Calcitonin gene-related peptide (CGRP) is an endogenous substance, which is regarded a key mediator released from trigeminovascular system after stimulation of sensory nerve endings, responsible for dilatation of peripheral vessels and sensory transmission. CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research. In the article we focus on the role of CGRP in the pathophysiology of migraine and present current data on CGRP antagonists and CGRP monoclonal antibodies.

Get Citation

Keywords

Calcitonin gene-related peptide, Migraine, Monoclonal antibodies, Calcitonin gene-related peptide antagonists

About this article
Title

Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 6 (2016)

Pages

463-467

DOI

10.1016/j.pjnns.2016.07.012

Bibliographic record

Neurol Neurochir Pol 2016;50(6):463-467.

Keywords

Calcitonin gene-related peptide
Migraine
Monoclonal antibodies
Calcitonin gene-related peptide antagonists

Authors

Olga Kuzawińska
Krzysztof Lis
Grzegorz Cessak
Dagmara Mirowska-Guzel
Ewa Bałkowiec-Iskra

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