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Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment
Affiliations- chair and department of experimental and clinical pharmacology, medical university of warsaw
- The Office for Registration of Medicinal Products, Medical Devices and Biocidal Products, Warsaw, Poland
- 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
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Abstract
Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. Calcitonin gene-related peptide (CGRP) is an endogenous substance, which is regarded a key mediator released from trigeminovascular system after stimulation of sensory nerve endings, responsible for dilatation of peripheral vessels and sensory transmission. CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research. In the article we focus on the role of CGRP in the pathophysiology of migraine and present current data on CGRP antagonists and CGRP monoclonal antibodies.
Abstract
Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. Calcitonin gene-related peptide (CGRP) is an endogenous substance, which is regarded a key mediator released from trigeminovascular system after stimulation of sensory nerve endings, responsible for dilatation of peripheral vessels and sensory transmission. CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research. In the article we focus on the role of CGRP in the pathophysiology of migraine and present current data on CGRP antagonists and CGRP monoclonal antibodies.
Keywords
Calcitonin gene-related peptide, Migraine, Monoclonal antibodies, Calcitonin gene-related peptide antagonists
About this articleTitle
Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
463-467
Page views
376
Article views/downloads
723
DOI
10.1016/j.pjnns.2016.07.012
Bibliographic record
Neurol Neurochir Pol 2016;50(6):463-467.
Keywords
Calcitonin gene-related peptide
Migraine
Monoclonal antibodies
Calcitonin gene-related peptide antagonists
Authors
Olga Kuzawińska
Krzysztof Lis
Grzegorz Cessak
Dagmara Mirowska-Guzel
Ewa Bałkowiec-Iskra
