open access

Vol 50, No 6 (2016)
Review article
Submitted: 2016-04-26
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Cerebral vasomotor reactivity in neurodegenerative diseases

Łukasz Smoliński, Anna Członkowska
DOI: 10.1016/j.pjnns.2016.07.011
·
Neurol Neurochir Pol 2016;50(6):455-462.

open access

Vol 50, No 6 (2016)
Review article
Submitted: 2016-04-26

Abstract

Small-caliber cerebral vessels change their diameters in response to alterations of key metabolite concentrations such as carbon dioxide or oxygen. This phenomenon, termed the cerebral vasomotor reactivity (CVMR), is the basis for blood flow regulation in the brain in accordance with its metabolic status. Typically, CVMR is determined as the amount of change in cerebral blood flow in response to a vasodilating stimulus, which can be measured by various neuroimaging methods or by transcranial Doppler. It has been shown that CVMR is impaired in cerebrovascular diseases, but there is also evidence of a similar dysfunction in neurodegenerative disorders. Here, we review studies that have investigated CVMR in the common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Moreover, we discuss potential neurodegenerative mechanisms responsible for the impairment of CVMR.

Abstract

Small-caliber cerebral vessels change their diameters in response to alterations of key metabolite concentrations such as carbon dioxide or oxygen. This phenomenon, termed the cerebral vasomotor reactivity (CVMR), is the basis for blood flow regulation in the brain in accordance with its metabolic status. Typically, CVMR is determined as the amount of change in cerebral blood flow in response to a vasodilating stimulus, which can be measured by various neuroimaging methods or by transcranial Doppler. It has been shown that CVMR is impaired in cerebrovascular diseases, but there is also evidence of a similar dysfunction in neurodegenerative disorders. Here, we review studies that have investigated CVMR in the common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Moreover, we discuss potential neurodegenerative mechanisms responsible for the impairment of CVMR.

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Keywords

Cerebral vasomotor reactivity, Alzheimer' s disease, Parkinson' s disease, Multiple sclerosis, Neurodegenerative disease

About this article
Title

Cerebral vasomotor reactivity in neurodegenerative diseases

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 50, No 6 (2016)

Pages

455-462

DOI

10.1016/j.pjnns.2016.07.011

Bibliographic record

Neurol Neurochir Pol 2016;50(6):455-462.

Keywords

Cerebral vasomotor reactivity
Alzheimer's disease
Parkinson's disease
Multiple sclerosis
Neurodegenerative disease

Authors

Łukasz Smoliński
Anna Członkowska

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