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Cerebral vasomotor reactivity in neurodegenerative diseases
Affiliations- Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
- Department of Clinical and Experimental Pharmacology, Medical University of Warsaw, Warsaw, Poland
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Abstract
Small-caliber cerebral vessels change their diameters in response to alterations of key metabolite concentrations such as carbon dioxide or oxygen. This phenomenon, termed the cerebral vasomotor reactivity (CVMR), is the basis for blood flow regulation in the brain in accordance with its metabolic status. Typically, CVMR is determined as the amount of change in cerebral blood flow in response to a vasodilating stimulus, which can be measured by various neuroimaging methods or by transcranial Doppler. It has been shown that CVMR is impaired in cerebrovascular diseases, but there is also evidence of a similar dysfunction in neurodegenerative disorders. Here, we review studies that have investigated CVMR in the common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Moreover, we discuss potential neurodegenerative mechanisms responsible for the impairment of CVMR.
Abstract
Small-caliber cerebral vessels change their diameters in response to alterations of key metabolite concentrations such as carbon dioxide or oxygen. This phenomenon, termed the cerebral vasomotor reactivity (CVMR), is the basis for blood flow regulation in the brain in accordance with its metabolic status. Typically, CVMR is determined as the amount of change in cerebral blood flow in response to a vasodilating stimulus, which can be measured by various neuroimaging methods or by transcranial Doppler. It has been shown that CVMR is impaired in cerebrovascular diseases, but there is also evidence of a similar dysfunction in neurodegenerative disorders. Here, we review studies that have investigated CVMR in the common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Moreover, we discuss potential neurodegenerative mechanisms responsible for the impairment of CVMR.
Keywords
Cerebral vasomotor reactivity, Alzheimer' s disease, Parkinson' s disease, Multiple sclerosis, Neurodegenerative disease
About this articleTitle
Cerebral vasomotor reactivity in neurodegenerative diseases
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
455-462
Page views
417
Article views/downloads
574
DOI
10.1016/j.pjnns.2016.07.011
Bibliographic record
Neurol Neurochir Pol 2016;50(6):455-462.
Keywords
Cerebral vasomotor reactivity
Alzheimer's disease
Parkinson's disease
Multiple sclerosis
Neurodegenerative disease
Authors
Łukasz Smoliński
Anna Członkowska
