open access
Recurrence-associated chromosomal anomalies in meningiomas: Single-institution study and a systematic review with meta-analysis
- Neurosurgery Department, Regional Specialist Hospital, Olsztyn, Poland
- Students’ Scientific Association, Neurosurgery Department, Medical University of Gdansk, Gdansk, Poland
- Department of Molecular Pathology and Neuropathology, Medical University of Łódź, Łódź, Poland
- Department of Preventive Medicine and Education, Medical University of Gdańsk, Gdańsk, Poland
- Neurosurgery and CNS Oncology Department, Medical University of Łódź, Poland
open access
Abstract
•WHO grade II or III and loss of heterozygosity (LOH) on 1p, and 14q are responsible for recurrence of a sporadic meningioma.•WHO grading has greater impact on further tumour behaviour than molecular findings.•Sparse reporting of the rate of resection prevents full meta-analysing.
Abstract
•WHO grade II or III and loss of heterozygosity (LOH) on 1p, and 14q are responsible for recurrence of a sporadic meningioma.•WHO grading has greater impact on further tumour behaviour than molecular findings.•Sparse reporting of the rate of resection prevents full meta-analysing.
Keywords
Meningioma, Loss of heterozygosity, Systematic review, Individual patient data, Meta-analysis
Title
Recurrence-associated chromosomal anomalies in meningiomas: Single-institution study and a systematic review with meta-analysis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
439-448
Page views
231
Article views/downloads
369
DOI
10.1016/j.pjnns.2016.08.003
Bibliographic record
Neurol Neurochir Pol 2016;50(6):439-448.
Keywords
Meningioma
Loss of heterozygosity
Systematic review
Individual patient data
Meta-analysis
Authors
Waldemar Och
Tomasz Szmuda
Beata Sikorska
Janusz Springer
Dariusz Jaskólski
Magdalena Zakrzewska
Paweł P. Liberski